PMID- 32038946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2223-3652 (Print)
IS  - 2223-3660 (Electronic)
IS  - 2223-3652 (Linking)
VI  - 9
IP  - 6
DP  - 2019 Dec
TI  - Patients over 70 years of age with moderate ischemic mitral regurgitation 
      undergoing surgical revascularization plus mitral valve repair: insights from a 
      single-center study of propensity-matched data.
PG  - 568-577
LID - 10.21037/cdt.2019.10.06 [doi]
AB  - BACKGROUND: Elderly patients, compared with the young, have a higher burden of 
      surgical risk factors with reduced functional capacity and increased 
      comorbidities conditions, and may have worse clinical outcomes. So far, few 
      reports have focused on clinical outcomes of patients over 70 years of age with 
      moderate chronic ischemic mitral regurgitation (IMR) undergoing mitral valve 
      repair at the time of coronary artery bypass grafting (CABG). This single-center 
      study of propensity-matched data attempts to answer a question: compared with 
      patients with age of 70 or less, whether patients over 70 years of age with 
      moderate IMR undergoing CABG plus mitral valve repair receive poor outcomes. 
      METHODS: All eligible patients were included in this study and were entered into 
      either an elderly group (n=142) or a control group (n=182) according to patients' 
      age. In-hospital outcomes (consisting of surgical mortality and major 
      postoperative morbidity) and midterm clinical outcomes (including all-cause 
      mortality and recurrent mitral regurgitation) were compared after propensity 
      score matching (1:1). RESULTS: Using propensity-score matching, 103 pairs of 
      patients were successfully established in a 1:1 ratio. No significant differences 
      between the two matched groups were found with regard to surgical mortality (5.8% 
      vs. 3.9%, P=0.754) and major postoperative morbidity. A total of 184 patients (91 
      in the elderly group and 93 in the control group) received regular follow-up 
      visit with the median duration of 38 months [interquartile range (IQR), 27-56 
      months]. There were not any significant differences between the two matched 
      groups regarding overall survival and recurrent IMR-free survival (stratified 
      log-rank P=0.185 and stratified log-rank P=0.453, respectively). The elderly 
      group as compared to the control group did not affect midterm mortality via cox 
      proportional hazard regression (propensity score adjusted hazard ratio, 1.143; 
      95% confidence interval, 0.761-1.943; P=0.285). CONCLUSIONS: Patients over 70 
      years of age with moderate chronic IMR undergoing combined CABG and mitral valve 
      repair may receive favorable in-hospital and midterm clinical outcomes.
CI  - 2019 Cardiovascular Diagnosis and Therapy. All rights reserved.
FAU - Ji, Qiang
AU  - Ji Q
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
FAU - Qi, Xiao-Min
AU  - Qi XM
AD  - Shanghai Municipal Institute of Cardiovascular Diseases, Shanghai 200032, China.
FAU - Shen, Jin-Qiang
AU  - Shen JQ
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
FAU - Wang, Yu-Lin
AU  - Wang YL
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
FAU - Yang, Ye
AU  - Yang Y
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
FAU - Ding, Wen-Jun
AU  - Ding WJ
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
FAU - Xia, Li-Min
AU  - Xia LM
AD  - Department of Cardiovascular Surgery of Zhongshan Hospital Fudan University, 
      Shanghai 200032, China.
AD  - Department of Cardiovascular Surgery of Xiamen Branch of Zhongshan Hospital Fudan 
      University, Xiamen 510530, China.
FAU - Wang, Chun-Sheng
AU  - Wang CS
AD  - Shanghai Municipal Institute of Cardiovascular Diseases, Shanghai 200032, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Cardiovasc Diagn Ther
JT  - Cardiovascular diagnosis and therapy
JID - 101601613
PMC - PMC6987517
OTO - NOTNLM
OT  - Elderly patients
OT  - coronary artery bypass grafting (CABG)
OT  - ischemic mitral regurgitation (IMR)
OT  - mitral valve repair
OT  - moderate
OT  - propensity-score matching
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/02/11 06:00
MHDA- 2020/02/11 06:01
PMCR- 2019/12/01
CRDT- 2020/02/11 06:00
PHST- 2020/02/11 06:00 [entrez]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/02/11 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - cdt-09-06-568 [pii]
AID - 10.21037/cdt.2019.10.06 [doi]
PST - ppublish
SO  - Cardiovasc Diagn Ther. 2019 Dec;9(6):568-577. doi: 10.21037/cdt.2019.10.06.