PMID- 32039626
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 67
IP  - 3
DP  - 2020 May
TI  - Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal 
      and breast cancer patients.
PG  - 668-676
LID - 190604N485 [pii]
LID - 10.4149/neo_2020_190604N485 [doi]
AB  - Structural chromosome aberrations are a predictive biomarker of cancer risk. 
      Conventional chromosome analysis widely used for these purposes detects unstable 
      chromosome aberrations that are eliminated during cell division. Stable 
      aberrations that may persist in the body and tend to accumulate during a lifetime 
      can be detected by fluorescence in situ hybridization (FISH). The aim of the 
      study was to investigate the level of chromosome damage in newly diagnosed cancer 
      patients and control subjects by FISH. Both groups of untreated cancer patients 
      had increased frequency of aberrant cells. However, chromosome damage affected 
      different cytogenetic endpoints. Stable translocations and cells with complex 
      rearrangements were elevated in breast cancer patients whereas unstable 
      chromosome aberrations (dicentric chromosomes and acentric fragments) were 
      elevated in gastrointestinal cancer patients. These associations observed in 
      nonsmokers were typically not pronounced in smokers (with the exception of 
      dicentric chromosomes in gastrointestinal patients). Exposure to tobacco smoke 
      increased aberrations in healthy controls but not in the cancer patients. Our 
      study suggests an association between cancer and stable chromosomal 
      rearrangements in breast cancer patients. Unstable aberrations elevated in 
      gastrointestinal cancer patients may be at least partly ascribed to the exposure 
      to diagnostic X-rays.
FAU - Kadlcikova, D
AU  - Kadlcikova D
AD  - Department of Genetics and Reproduction, Central European Institute of Technology 
      - Veterinary Research Institute, Brno, Czech Republic.
FAU - Musilova, P
AU  - Musilova P
AD  - Department of Genetics and Reproduction, Central European Institute of Technology 
      - Veterinary Research Institute, Brno, Czech Republic.
FAU - Hradska, H
AU  - Hradska H
AD  - Department of Genetics and Reproduction, Central European Institute of Technology 
      - Veterinary Research Institute, Brno, Czech Republic.
FAU - Petrovova, M
AU  - Petrovova M
AD  - Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, 
      Czech Republic.
FAU - Selingerova, I
AU  - Selingerova I
AD  - Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer 
      Institute, Brno, Czech Republic.
FAU - Vozdova, M
AU  - Vozdova M
AD  - Department of Genetics and Reproduction, Central European Institute of Technology 
      - Veterinary Research Institute, Brno, Czech Republic.
FAU - Svoboda, M
AU  - Svoboda M
AD  - Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, 
      Czech Republic.
FAU - Rubes, J
AU  - Rubes J
AD  - Department of Genetics and Reproduction, Central European Institute of Technology 
      - Veterinary Research Institute, Brno, Czech Republic.
LA  - eng
PT  - Journal Article
DEP - 20200209
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - *Chromosome Aberrations
MH  - Gastrointestinal Neoplasms/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphocytes
EDAT- 2020/02/11 06:00
MHDA- 2020/09/10 06:00
CRDT- 2020/02/11 06:00
PHST- 2019/06/04 00:00 [received]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
AID - 190604N485 [pii]
AID - 10.4149/neo_2020_190604N485 [doi]
PST - ppublish
SO  - Neoplasma. 2020 May;67(3):668-676. doi: 10.4149/neo_2020_190604N485. Epub 2020 
      Feb 9.