PMID- 32039628
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 67
IP  - 3
DP  - 2020 May
TI  - Association of interleukine-18 polymorphisms with susceptibility to prostate 
      cancer in Iranian population.
PG  - 644-649
LID - 190616N513 [pii]
LID - 10.4149/neo_2020_190616N513 [doi]
AB  - Interleukin-18 (IL-18) is a multifunctional cytokine that augments interferon-gamma 
      production, promotion of the Th1 immune response and acts as an important 
      immunomediator in the development of some cancers. The current study aimed to 
      analyze the association of the five most common polymorphisms in the IL-18 gene 
      with prostate cancer in the Iranian population. We examined a possible 
      association of IL-18 -137G>C, -607C>A, -656G>T, +105A>C and +127C>T polymorphisms 
      with prostate cancer occurrence by PCR-RFLP assay. Odds ratio (OR) and 95% 
      confidence interval (CI) were used to assess the strength of the association 
      between IL-18 polymorphisms and prostate cancer. Statistical analysis revealed 
      that individuals carrying the mutant homozygote genotype of IL-18 -607C>A 
      (OR=2.251, 95% CI=1.062-4.768, p=0.034) and -137G>C (OR=2.364, 95% 
      CI=1.121-4.984, p=0.024) polymorphisms had an increased risk of prostate cancer. 
      However, for IL-18 -656G>T, +105A>C and +127C>T polymorphisms, there were no 
      differential distributions of their genotypes between patients with prostate 
      cancer and healthy subjects. Our results indicated that the IL-18 -137G>C and 
      -607C>A polymorphisms were significantly associated with an increased risk of 
      prostate cancer in the Iranian population. Thus, these polymorphisms might be 
      used as a molecular biomarker in the early diagnosis of prostate cancer.
FAU - Abedinzadeh, M
AU  - Abedinzadeh M
AD  - Department of Urology, Shahid Rahnamoun Hospital, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Ghodsian, M
AU  - Ghodsian M
AD  - Department of Urology, Shahid Rahnamoun Hospital, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Dastgheib, S Alireza
AU  - Dastgheib SA
AD  - Department of Medical Genetics, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Jafari-Nedooshan, J
AU  - Jafari-Nedooshan J
AD  - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Zare, M
AU  - Zare M
AD  - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Heiranizadeh, N
AU  - Heiranizadeh N
AD  - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Raee-Ezzabadi, A
AU  - Raee-Ezzabadi A
AD  - Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Neamatzadeh, H
AU  - Neamatzadeh H
AD  - Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
AD  - Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200209
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Interleukin-18)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Iran
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Prostatic Neoplasms/*genetics
EDAT- 2020/02/11 06:00
MHDA- 2020/09/10 06:00
CRDT- 2020/02/11 06:00
PHST- 2019/06/16 00:00 [received]
PHST- 2019/08/21 00:00 [accepted]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
AID - 190616N513 [pii]
AID - 10.4149/neo_2020_190616N513 [doi]
PST - ppublish
SO  - Neoplasma. 2020 May;67(3):644-649. doi: 10.4149/neo_2020_190616N513. Epub 2020 
      Feb 9.