PMID- 32040598
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 1432-5195 (Electronic)
IS  - 0341-2695 (Linking)
VI  - 44
IP  - 6
DP  - 2020 Jun
TI  - Proximal fibular osteotomy alleviates medial compartment knee osteoarthritis in a 
      mouse model.
PG  - 1107-1113
LID - 10.1007/s00264-020-04497-x [doi]
AB  - PURPOSE: The purpose of this study was to establish a mouse model of proximal 
      fibular osteotomy (PFO), and to determine if PFO could delay degeneration of the 
      medial compartment of the knee joint in a mouse model. METHODS: An animal model 
      of destabilization of the medial meniscus (DMM) was used to induce post-traumatic 
      knee osteoarthritis (OA). PFO was performed to examine the effectiveness of PFO 
      on protection against medial compartment knee OA. Micro-CT was used to observe 
      osteosclerosis development in the subchondral bone, and Safranin O-fast green 
      staining was used to evaluate the progression of articular cartilage destruction. 
      The condylar-plateau angle (CPA) and anatomical femorotibial angle (aFTA) were 
      measured to determine whether knee alignment was changed after PFO. RESULTS: PFO 
      treatment could decrease osteophyte formation and osteosclerosis development in 
      the subchondral bone, as observed by micro-CT. The value of the ratio of 
      trabecular bone volume to total volume (BV/TV) of DMM+PFO group was lower than 
      that of DMM group. PFO also inhibited the progression of articular cartilage 
      destruction. DMM + PFO group displayed decreased maximal and summed OA scores, as 
      compared with DMM group. Moreover, the change of knee alignment was reduced by 
      PFO, which might be the mechanism of PFO alleviating medial compartment knee OA. 
      CONCLUSION: Our results indicated that PFO could alleviate medial compartment 
      knee OA in a mouse model.
FAU - Wang, Tian-Rui
AU  - Wang TR
AD  - Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, 
      No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's 
      Republic of China.
AD  - Key Laboratory of Biomechanics of Hebei Province, The Third Hospital of Hebei 
      Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.
FAU - Wang, Hong-De
AU  - Wang HD
AD  - Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, 
      No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's 
      Republic of China.
AD  - Key Laboratory of Biomechanics of Hebei Province, The Third Hospital of Hebei 
      Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, 
      No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's 
      Republic of China.
AD  - Key Laboratory of Biomechanics of Hebei Province, The Third Hospital of Hebei 
      Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.
FAU - Yu, Teng-Bo
AU  - Yu TB
AD  - Department of Orthopedic Surgery, Affiliated Hospital of Qingdao University, 
      Qingdao, 266003, Shandong, People's Republic of China.
FAU - Qin, Yan
AU  - Qin Y
AD  - Department of Biochemistry and Molecular Biology, Hebei Medical university, 
      Shijiazhuang, 050017, People's Republic of China.
FAU - Zhang, Ying-Ze
AU  - Zhang YZ
AUID- ORCID: 0000-0002-2161-7785
AD  - Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, 
      No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's 
      Republic of China. acadyzzhang@126.com.
AD  - Key Laboratory of Biomechanics of Hebei Province, The Third Hospital of Hebei 
      Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China. 
      acadyzzhang@126.com.
AD  - Chinese Academy of Engineering, Beijing, People's Republic of China. 
      acadyzzhang@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200210
PL  - Germany
TA  - Int Orthop
JT  - International orthopaedics
JID - 7705431
SB  - IM
MH  - Animals
MH  - Cartilage, Articular
MH  - Disease Models, Animal
MH  - Female
MH  - Fibula/surgery
MH  - Knee Joint/surgery
MH  - Male
MH  - Menisci, Tibial/surgery
MH  - Mice
MH  - Osteoarthritis, Knee/*surgery
MH  - Osteophyte
MH  - *Osteotomy
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - Cartilage
OT  - Destabilization of the medial meniscus
OT  - Micro-CT
OT  - Osteoarthritis
OT  - Proximal fibular osteotomy
EDAT- 2020/02/11 06:00
MHDA- 2021/04/02 06:00
CRDT- 2020/02/11 06:00
PHST- 2019/08/08 00:00 [received]
PHST- 2020/01/31 00:00 [accepted]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
AID - 10.1007/s00264-020-04497-x [pii]
AID - 10.1007/s00264-020-04497-x [doi]
PST - ppublish
SO  - Int Orthop. 2020 Jun;44(6):1107-1113. doi: 10.1007/s00264-020-04497-x. Epub 2020 
      Feb 10.