PMID- 32040618
OWN - NLM
STAT- MEDLINE
DCOM- 20200921
LR  - 20200921
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 50
IP  - 8
DP  - 2020 Aug
TI  - Prognostic impact of CD8+ T cell distribution and its association with the HLA 
      class I expression in intrahepatic cholangiocarcinoma.
PG  - 931-940
LID - 10.1007/s00595-020-01967-y [doi]
AB  - PURPOSE: A lack of effective systemic therapy is one reason for the poor 
      prognosis of intrahepatic cholangiocarcinoma. Newly developed immune checkpoint 
      inhibitors function by minimizing CD8+ T cell suppression to improve 
      tumor-specific responses. This study aimed to examine the characteristics of CD8+ 
      T cells in intrahepatic cholangiocarcinoma. METHODS: Clinicopathological data, 
      including the overall survival, of 69 cases of postoperative intrahepatic 
      cholangiocarcinoma were prospectively investigated. We then immunohistochemically 
      stained for CD8, Foxp3, CD163, PD-L1, and human leukocyte antigen (HLA) class I 
      and counted the number of CD8+ T cells, Foxp3+ T cells, and CD163+ macrophages in 
      different areas (outer border, interborder, and intratumor). RESULTS: A 
      significant difference was found in the 5-year overall survival between the CD8+ 
      T cell high group (45.5%) and low group (24.7%) in the outer border area 
      (p = 0.0103). Furthermore, the number of CD8+ T cells and the high expression of 
      HLA class I were positively correlated (p = 0.0341). CONCLUSION: The number of 
      CD8+ T cells in the outer border area of the tumor correlated with the HLA class 
      I expression of intrahepatic cholangiocarcinoma and may therefore be a prognostic 
      factor for patients with postoperative intrahepatic cholangiocarcinoma.
FAU - Asahi, Yoh
AU  - Asahi Y
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Hatanaka, Kanako C
AU  - Hatanaka KC
AD  - Clinical Biobank, Clinical Research and Medical Innovation Center, Hokkaido 
      University Hospital, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, 
      Japan.
FAU - Hatanaka, Yutaka
AU  - Hatanaka Y
AD  - Research Division of Genome Companion Diagnostics, Hokkaido University Hospital, 
      Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Kamiyama, Toshiya
AU  - Kamiyama T
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Orimo, Tatsuya
AU  - Orimo T
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Shimada, Shingo
AU  - Shimada S
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Nagatsu, Akihisa
AU  - Nagatsu A
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Sakamoto, Yuzuru
AU  - Sakamoto Y
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Kamachi, Hirofumi
AU  - Kamachi H
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Kobayashi, Nozomi
AU  - Kobayashi N
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Fukai, Moto
AU  - Fukai M
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
FAU - Taketomi, Akinobu
AU  - Taketomi A
AD  - Department of Gastroenterological Surgery I, Hokkaido University Graduate School 
      of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan. 
      taketomi@med.hokudai.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200210
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Bile Duct Neoplasms/*genetics/*immunology/mortality/surgery
MH  - Biliary Tract Surgical Procedures
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cholangiocarcinoma/*genetics/*immunology/mortality/surgery
MH  - Female
MH  - *Gene Expression
MH  - Histocompatibility Antigens Class I/*genetics/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Survival Rate
OTO - NOTNLM
OT  - CD8+ T cell
OT  - Cholangiocarcinoma
OT  - HLA class I
OT  - Intrahepatic cholangiocarcinoma
OT  - PD-L1
EDAT- 2020/02/11 06:00
MHDA- 2020/09/22 06:00
CRDT- 2020/02/11 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2020/01/10 00:00 [accepted]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/09/22 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
AID - 10.1007/s00595-020-01967-y [pii]
AID - 10.1007/s00595-020-01967-y [doi]
PST - ppublish
SO  - Surg Today. 2020 Aug;50(8):931-940. doi: 10.1007/s00595-020-01967-y. Epub 2020 
      Feb 10.