PMID- 32040830
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 15
IP  - 2
DP  - 2020 Mar
TI  - Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a 
      systematic review.
PG  - 327-331
LID - 10.1007/s11739-020-02287-2 [doi]
AB  - The aim of this systematic review was to assess AKI (acute kidney injury) in 
      adult patients, treated with vancomycin (V) + piperacillin/tazobactam (PT) 
      compared to V monotherapy. Studies were found in Pubmed, Web of Science and 
      Scopus databases. Articles not in English, pediatric studies and case reports 
      were excluded. A study is eligible for inclusion if the adjusted Odds ratio (aOR) 
      for AKI in V + PT compared to V monotherapy groups, could be extracted or 
      determined from available data. Six retrospective cohort studies were eligible 
      for inclusion criteria and so they were included in the analysis. All studies 
      separately showed a significant higher risk of developing AKI (OR > 1, p < 0.05) 
      in V + PT group compared to V monotherapy group. Considering the methodological 
      difference of included studies, a random effect model was preferred. The model 
      showed a pooled significant higher risk of developing AKI [OR 2.77 (95% CI 1.94, 
      3.96), p < 0.0001] in V + PT group compared to V group. Association of V and PT 
      appears to be associated with a greater risk of AKI compared to V in monotherapy. 
      These results may serve as the impetus for further evaluation into true 
      mechanisms behind this additive nephrotoxic effect and its potential implications 
      on mortality.
FAU - Ciarambino, Tiziana
AU  - Ciarambino T
AD  - Hospital of Marcianise, ASL Caserta, Marcianise, Italy. 
      tiziana.ciarambino@gmail.com.
FAU - Giannico, Orazio Valerio
AU  - Giannico OV
AD  - Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, 
      Italy.
FAU - Campanile, Amalia
AU  - Campanile A
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania "L. 
      Vanvitelli", 80138, Naples, Italy.
FAU - Tirelli, Paolo
AU  - Tirelli P
AD  - Department of Internal Medicine, Hospital of Mare, Naples, Italy.
FAU - Para, Ombretta
AU  - Para O
AD  - Department of Internal Medicine, Hospital of Careggi, University of Florence, 
      Florence, Italy.
FAU - Signoriello, Giuseppe
AU  - Signoriello G
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania "L. 
      Vanvitelli", 80138, Naples, Italy.
FAU - Giordano, Mauro
AU  - Giordano M
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania "L. 
      Vanvitelli", 80138, Naples, Italy.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20200210
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
RN  - SE10G96M8W (Tazobactam)
RN  - X00B0D5O0E (Piperacillin)
SB  - IM
MH  - Acute Kidney Injury/*etiology
MH  - Adult
MH  - Anti-Bacterial Agents/adverse effects/therapeutic use
MH  - Drug Therapy, Combination/adverse effects/*standards
MH  - Humans
MH  - Piperacillin/*adverse effects/therapeutic use
MH  - Tazobactam/*adverse effects/therapeutic use
MH  - Vancomycin/*adverse effects/therapeutic use
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Adult patients
OT  - Piperacillin/tazobactam
OT  - Vancomycin
EDAT- 2020/02/11 06:00
MHDA- 2020/11/11 06:00
CRDT- 2020/02/11 06:00
PHST- 2019/08/12 00:00 [received]
PHST- 2020/01/28 00:00 [accepted]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
AID - 10.1007/s11739-020-02287-2 [pii]
AID - 10.1007/s11739-020-02287-2 [doi]
PST - ppublish
SO  - Intern Emerg Med. 2020 Mar;15(2):327-331. doi: 10.1007/s11739-020-02287-2. Epub 
      2020 Feb 10.