PMID- 32040898 OWN - NLM STAT- MEDLINE DCOM- 20200226 LR - 20200226 IS - 0869-2084 (Print) IS - 0869-2084 (Linking) VI - 64 IP - 12 DP - 2019 TI - [The estimation of the hepatitis E proportion in the etiological structure of acute viral hepatitis in certain regions of of Kyrgyzstan.]. PG - 740-746 LID - 10.18821/0869-2084-2019-64-12-740-746 [doi] AB - Despite the fact that the Kyrgyz Republic (KR) belongs to the highly endemic regions of the world for hepatitis E, the true extent of the spread of this infection in the country remains poorly understood. It was estimated the prevalence of serological markers of hepatitis E virus (HEV) infection among patients with acute viral hepatitis (AVH) from the regions of the Kyrgyz Republic with a high level of seroprevalence previously established by us. Blood sera samples of hepatitis patients who were admitted to hospitals of Kyrgyzstan in the period 2018-2019 were examined by the enzyme immunoassay method using the kits <> and <> (RPC Diagnostic Systems, Russia). IgG and IgM antibodies to HEV were detected in 103 of 344 studied samples (29.9%). Most often, seropositive specimens were detected among people of age groups under 20 and over 40 years old. Hepatitis with the fecal-oral mode of transmission was dominated in the structure of AVH: the specific gravity of hepatitis E was 47.9%, hepatitis A - 35.32%. Markers of mixed infections with other hepatitis viruses have been detected in 40.4% IgM-positive individuals. Thus, high prevalence of serological markers of HEV infection in the territory of Kyrgyzstan during the interepidemic period had been shown. The necessity of including the determination of serological markers of hepatitis E into the algorithm for the comprehensive diagnosis of AVH in patients of all age groups with liver pathology had been confirmed. FAU - Alatortseva, G I AU - Alatortseva GI AUID- ORCID: 0000-0001-9887-4061 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. FAU - Lukhverchik, L N AU - Lukhverchik LN AUID- ORCID: 0000-0002-2997-8892 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. FAU - Nesterenko, L N AU - Nesterenko LN AUID- ORCID: 0000-0002-3825-3906 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. FAU - Dotsenko, V V AU - Dotsenko VV AUID- ORCID: 0000-0002-5866-944X AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. FAU - Amiantova, I I AU - Amiantova II AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. FAU - Mikhailov, M I AU - Mikhailov MI AUID- ORCID: 0000-0002-6636-6801 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. AD - Russian Medical Academy of Postgraduate Education of the Ministry of Healthcare of the Russian Federation, 125993, Moscow, Russia. FAU - Kyuregian, K K AU - Kyuregian KK AUID- ORCID: 0000-0002-3599-117X AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. AD - Russian Medical Academy of Postgraduate Education of the Ministry of Healthcare of the Russian Federation, 125993, Moscow, Russia. FAU - Malinnikova, E Y AU - Malinnikova EY AUID- ORCID: 0000-0002-5501-5707 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. AD - Russian Medical Academy of Postgraduate Education of the Ministry of Healthcare of the Russian Federation, 125993, Moscow, Russia. FAU - Nurmatov, Z S AU - Nurmatov ZS AUID- ORCID: 0000-0003-3481-227X AD - Scientific Production Association <> Ministry of Health of the Kyrgyz Republic, 720005, Bishkek, Kyrgyz Republic. FAU - Nurmatov, A Z AU - Nurmatov AZ AUID- ORCID: 0000-0002-0717-4172 AD - Scientific Production Association <> Ministry of Health of the Kyrgyz Republic, 720005, Bishkek, Kyrgyz Republic. FAU - Tashov, K E AU - Tashov KE AUID- ORCID: 0000-0002-3059-3834 AD - Osh Interregional Joint Clinical Hospital, 714000, Osh, Kyrgyz Republic. FAU - Kasymov, O T AU - Kasymov OT AUID- ORCID: 0000-0002-3304-7409 AD - Scientific Production Association <> Ministry of Health of the Kyrgyz Republic, 720005, Bishkek, Kyrgyz Republic. FAU - Zverev, V V AU - Zverev VV AUID- ORCID: 0000-0002-0017-1892 AD - Federal State Budgetary Scientific Institution <>, 105064, Moscow, Russia. LA - rus GR - RFMEFI61319X0091/The Ministry of Science and Higher Education of the Russian Federation/ PT - Journal Article PL - Russia (Federation) TA - Klin Lab Diagn JT - Klinicheskaia laboratornaia diagnostika JID - 9432021 RN - 0 (Antibodies, Viral) RN - 0 (Immunoglobulin G) RN - 0 (Immunoglobulin M) RN - 0 (RNA, Viral) SB - IM MH - Adult MH - Antibodies, Viral/blood MH - Enzyme-Linked Immunosorbent Assay MH - Hepatitis A/epidemiology MH - Hepatitis E/*epidemiology/transmission MH - *Hepatitis E virus MH - Hepatitis, Viral, Human/*epidemiology/virology MH - Humans MH - Immunoglobulin G/blood MH - Immunoglobulin M/blood MH - Kyrgyzstan/epidemiology MH - RNA, Viral MH - Seroepidemiologic Studies MH - Young Adult OTO - NOTNLM OT - HEV OT - acute viral hepatitis OT - anti-HEV IgG OT - anti-HEV IgM OT - hepatitis E virus OT - seroepidemiology COIS- The authors declare no conflict of interest. EDAT- 2020/02/11 06:00 MHDA- 2020/02/27 06:00 CRDT- 2020/02/11 06:00 PHST- 2019/11/07 00:00 [received] PHST- 2019/11/11 00:00 [accepted] PHST- 2020/02/11 06:00 [entrez] PHST- 2020/02/11 06:00 [pubmed] PHST- 2020/02/27 06:00 [medline] AID - 10.18821/0869-2084-2019-64-12-740-746 [doi] PST - ppublish SO - Klin Lab Diagn. 2019;64(12):740-746. doi: 10.18821/0869-2084-2019-64-12-740-746.