PMID- 32041444
OWN - NLM
STAT- MEDLINE
DCOM- 20210416
LR  - 20210416
IS  - 1552-6941 (Electronic)
IS  - 1534-7346 (Linking)
VI  - 19
IP  - 2
DP  - 2020 Jun
TI  - Association of Circulating Osteopontin Levels With Lower Extremity Arterial 
      Disease in Subjects With Type 2 Diabetes Mellitus: A Cross-Sectional 
      Observational Study.
PG  - 180-189
LID - 10.1177/1534734619898097 [doi]
AB  - Osteopontin (OPN) is involved in the atherosclerotic and inflammatory process. In 
      this article, we examined the relationship between circulating OPN levels with 
      lower extremity arterial disease (LEAD) in individuals with type 2 diabetes 
      mellitus (T2DM). Seventy individuals with T2DM and 66 individuals without T2DM 
      were recruited. Diagnosis of LEAD was based on the absence of triphasic waveform 
      on the pedal arteries. Plasma OPN levels were determined by Luminex Multiplex 
      immunoassay. LEAD was present in 34 (48.6%) patients with T2DM. In the diabetes 
      cohort, individuals with LEAD had higher plasma OPN concentrations than those 
      without LEAD (geometric mean [95% confidence intervals]; 43.4 [37.5-50.4] vs 26.1 
      [22.9-29.8] ng/mL, respectively, P < .001). Multivariable analysis showed that 
      presence of LEAD independently associated with higher OPN levels in subjects with 
      T2DM, with marginal statistical significance (P = .049). In both cohorts, plasma 
      OPN concentrations were negatively associated with ankle-brachial index values (P 
      < .05). In the total sample, there was a gradual increase of OPN levels across 
      subgroups with triphasic, biphasic, and monophasic/blunted waveforms (P < .001). 
      In conclusion, plasma OPN levels are associated with the presence and severity of 
      LEAD in subjects with T2DM. Further studies are needed to investigate the role of 
      OPN in the pathogenesis and progression of LEAD.
FAU - Eleftheriadou, Ioanna
AU  - Eleftheriadou I
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Tsilingiris, Dimitrios
AU  - Tsilingiris D
AUID- ORCID: 0000-0002-6864-4289
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Tentolouris, Anastasios
AU  - Tentolouris A
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Mourouzis, Iordanis
AU  - Mourouzis I
AD  - Department of Pharmacology, Medical School, National and Kapodistrian University 
      of Athens, Athens, Greece.
FAU - Grigoropoulou, Pinelopi
AU  - Grigoropoulou P
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Kapelios, Christos
AU  - Kapelios C
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Pantos, Constantinos
AU  - Pantos C
AD  - Department of Pharmacology, Medical School, National and Kapodistrian University 
      of Athens, Athens, Greece.
FAU - Makrilakis, Konstantinos
AU  - Makrilakis K
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
FAU - Tentolouris, Nikolaos
AU  - Tentolouris N
AD  - Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical 
      School, National and Kapodistrian University of Athens, Laiko General Hospital, 
      Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200211
PL  - United States
TA  - Int J Low Extrem Wounds
JT  - The international journal of lower extremity wounds
JID - 101128359
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Ankle Brachial Index/methods
MH  - Correlation of Data
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diabetic Neuropathies/diagnosis
MH  - Female
MH  - Humans
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Osteopontin/*blood
MH  - *Peripheral Arterial Disease/blood/diagnosis/physiopathology
MH  - *Peripheral Nervous System Diseases/diagnosis/etiology
MH  - Pulse Wave Analysis/methods
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - cardiac autonomic neuropathy
OT  - nephropathy
OT  - osteopontin
OT  - peripheral artery disease
OT  - peripheral neuropathy
OT  - type 2 diabetes mellitus
EDAT- 2020/02/12 06:00
MHDA- 2021/04/17 06:00
CRDT- 2020/02/12 06:00
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2021/04/17 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
AID - 10.1177/1534734619898097 [doi]
PST - ppublish
SO  - Int J Low Extrem Wounds. 2020 Jun;19(2):180-189. doi: 10.1177/1534734619898097. 
      Epub 2020 Feb 11.