PMID- 32041504
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20201214
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 29
IP  - 4
DP  - 2020 Apr
TI  - Serum and urine TNF-like weak inducer of apoptosis, monocyte chemoattractant 
      protein-1 and neutrophil gelatinase-associated lipocalin as biomarkers of disease 
      activity in patients with systemic lupus erythematosus.
PG  - 379-388
LID - 10.1177/0961203320904997 [doi]
AB  - OBJECTIVES: TNF-like weak inducer of apoptosis (TWEAK), monocyte chemoattractant 
      protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) are 
      proinflammatory cytokines/chemokines that are considered as potential biomarkers 
      reflecting disease activity in systemic lupus erythematosus (SLE). In this study, 
      we aimed to investigate the association of serum (s) and urine (u) levels of 
      TWEAK, MCP-1 and NGAL with disease activity in both renal and extra-renal SLE. 
      METHODS: Thirty active patients with SLE (15 renal and 15 extra-renal) were 
      recruited. Thirty-one inactive patients with SLE (16 renal and 15 extra-renal), 
      14 patients with ANCA-associated vasculitis (AAV) all of whom had active renal 
      involvement and 20 healthy volunteers were selected as control groups. Serum and 
      urine levels of TWEAK, MCP-1 and NGAL were tested using ELISA. RESULTS: Serum and 
      urine levels of TWEAK and NGAL were significantly higher in the active SLE group 
      compared to the inactive SLE group (sTWEAK p = 0.005; uTWEAK p = 0.026; sNGAL 
      p < 0.001; uNGAL p = 0.002), whilst no significant differences regarding serum 
      and urine MCP-1 levels were observed (p = 0.189 and p = 0.106, respectively). 
      uTWEAK (p = 0.237), sMCP-1 (p = 0.141), uMCP-1 (p = 0.206), sNGAL (p = 0.419) and 
      uNGAL (p = 0.443) levels did not differ between patients with active renal and 
      extra-renal SLE. Serum TWEAK was higher in patients with active renal SLE 
      (p = 0.006). There were no differences between active renal SLE and active renal 
      AAV. Levels of all biomarkers were correlated with the SLE Disease Activity 
      Index. CONCLUSION: sTWEAK, uTWEAK, sNGAL and uNGAL are biomarkers showing disease 
      activity in SLE. However, our results implicate that these biomarkers may not be 
      specific for SLE, and can be elevated in patients with active renal involvement 
      of AAV.
FAU - Mirioglu, S
AU  - Mirioglu S
AUID- ORCID: 0000-0003-0362-8154
AD  - Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Cinar, S
AU  - Cinar S
AD  - Department of Immunology, Aziz Sancar Institute of Experimental Medicine, 
      Istanbul University, Istanbul, Turkey.
FAU - Yazici, H
AU  - Yazici H
AD  - Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Ozluk, Y
AU  - Ozluk Y
AD  - Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Kilicaslan, I
AU  - Kilicaslan I
AD  - Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Gul, A
AU  - Gul A
AD  - Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Ocal, L
AU  - Ocal L
AD  - Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Inanc, M
AU  - Inanc M
AD  - Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Artim-Esen, B
AU  - Artim-Esen B
AUID- ORCID: 0000-0002-5659-3955
AD  - Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200210
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokine TWEAK)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Lipocalin-2)
RN  - 0 (TNFSF12 protein, human)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/blood
MH  - Apoptosis/immunology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood/urine
MH  - Cross-Sectional Studies
MH  - Cytokine TWEAK/*blood/urine
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Lipocalin-2/*blood/urine
MH  - Lupus Erythematosus, Systemic/diagnosis/drug therapy/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factors/blood/urine
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - MCP-1
OT  - NGAL
OT  - Systemic lupus erythematosus
OT  - TWEAK
OT  - biomarkers
OT  - lupus nephritis
EDAT- 2020/02/12 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/02/12 06:00
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
AID - 10.1177/0961203320904997 [doi]
PST - ppublish
SO  - Lupus. 2020 Apr;29(4):379-388. doi: 10.1177/0961203320904997. Epub 2020 Feb 10.