PMID- 3204254
OWN - NLM
STAT- MEDLINE
DCOM- 19890206
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 82
IP  - 6
DP  - 1988 Dec
TI  - Cytologic changes in the nasal secretions during the immediate nasal response.
PG  - 1103-12
AB  - In 102 randomly selected patients with allergic rhinitis caused by immediate 
      hypersensitivity, nasal provocation tests (NPTs) with allergens were evaluated by 
      means of rhinomanometry, and cytologic examination of the nasal secretions (NSs) 
      was performed. The cells in NS of 117 positive immediate nasal responses (INRs) 
      and in 68 negative INRs, correlating with history and skin tests, and in 102 
      control challenges with phosphate-buffered saline were stained by modified 
      May-Grunwald-Giemsa, toluidine blue, and Hansel's method. The positive INR was 
      accompanied by significant changes in the count of eosinophils (increase followed 
      by decrease) in 67% of neutrophils (decrease followed by increase) in 40%, goblet 
      cells (increase followed by decrease) in 41%, and basophils (decrease) in 13% of 
      the NSs. No significant changes in the count of other types of cells in the NSs 
      were recorded during most of the cases of INR. No significant changes in the 
      count of individual cell types in NSs were found during most cases of negative 
      INR. During the phosphate-buffered saline control challenges, the individual cell 
      types appeared irregularly, and no significant changes in their count were 
      recorded in any patient. The cytologic examination of NS, evoked by allergen, 
      appears therefore to be a valuable supplementary diagnostic parameter for nasal 
      allergy. The repeated counting of eosinophils in NS, before and after allergen 
      challenge, appears to be the best way to discriminate between positive and 
      negative nasal responses, since the eosinophils demonstrated significant changes 
      in their count during 67% of the positive and only 11% of the negative INRs.
FAU - Pelikan, Z
AU  - Pelikan Z
AD  - Department of Allergology and Immunology, Institute of Medical Sciences De 
      Klokkenberg, Breda, The Netherlands.
FAU - Pelikan-Filipek, M
AU  - Pelikan-Filipek M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
EIN - J Allergy Clin Immunol 1989 May;83(5):870
MH  - Adult
MH  - Basophils
MH  - Eosinophils
MH  - Epithelium
MH  - Humans
MH  - Hypersensitivity, Immediate/*pathology
MH  - *Leukocyte Count
MH  - Lymphocytes
MH  - Mast Cells
MH  - Middle Aged
MH  - Nasal Mucosa/*metabolism
MH  - *Nasal Provocation Tests
MH  - Neutrophils
MH  - Sodium Chloride
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 0091-6749(88)90150-9 [pii]
AID - 10.1016/0091-6749(88)90150-9 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1988 Dec;82(6):1103-12. doi: 
      10.1016/0091-6749(88)90150-9.