PMID- 32043233
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Feb
TI  - Functional connectivity density abnormalities and anxiety in primary insomnia 
      patients.
PG  - 114-121
LID - 10.1007/s11682-019-00238-w [doi]
AB  - Primary insomnia (PI) is strongly associated with emotional dysregulation. 
      However, the neurobiological pathology of the association between PI and 
      emotional dysregulation is limited. Previous studies have indicated an impact of 
      PI on the emotional regulatory system, but the specificity of this finding 
      remains to be confirmed. A sample of 27 primary insomnia patients (PIs) and 32 
      matched healthy controls (HCs) was recruited for this study. The functional 
      connectivity density (FCD) was used to assess the spontaneous functional brain 
      organization in PIs. Then, we identified whether the local (lFCD) and global FCD 
      (gFCD) abnormalities can be the potential biomarker for emotion level in PIs. Our 
      findings suggested that PIs exhibited higher levels of anxiety and depression, 
      and the levels of anxiety and depression is associated with the insomnia 
      severity. We also found that PIs showed both lower lFCD and gFCD in several 
      regions (i.e. thalamus, anterior cingulate cortex (ACC), insula). Furthermore, 
      the lower gFCD values of left ACC and right insula were associated with their 
      anxiety level in PIs, which demonstrated their potential biomarker for anxiety in 
      PIs. Our results demonstrated that the relationship between the insomnia severity 
      and the anxiety level could be partially mediated by gFCD of the ACC and insula. 
      The current study improved our understanding of the anxiety in PIs and provided 
      helpful information for future therapeutic development for PIs.
FAU - Zhu, Yifei
AU  - Zhu Y
AD  - Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong 
      University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi-Province, People's 
      Republic of China. zhuyunjia1988@outlook.com.
AD  - Department of Psychosomatic Medicine, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, People's Republic of China. zhuyunjia1988@outlook.com.
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, No. 215 
      Heping West Road, Xinhua District, Shijiazhuang, 050000, People's Republic of 
      China. zhuyunjia1988@outlook.com.
FAU - Zhao, Xumeng
AU  - Zhao X
AD  - Department of Psychosomatic Medicine, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, People's Republic of China.
FAU - Yin, Hua
AU  - Yin H
AD  - Department of Psychosomatic Medicine, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, People's Republic of China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong 
      University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi-Province, People's 
      Republic of China. zhangming01@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Anxiety
MH  - Brain Mapping
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
MH  - *Sleep Initiation and Maintenance Disorders/diagnostic imaging
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Anxiety
OT  - Functional connectivity density
OT  - Insomnia
OT  - Insula
EDAT- 2020/02/12 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/02/12 06:00
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
AID - 10.1007/s11682-019-00238-w [pii]
AID - 10.1007/s11682-019-00238-w [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2021 Feb;15(1):114-121. doi: 10.1007/s11682-019-00238-w.