PMID- 32043256
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20211103
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 30
IP  - 6
DP  - 2020 Jun
TI  - Long-term Impact of Mini-Gastric Bypass on Inflammatory Cytokines in Cohort of 
      Morbidly Obese Patients: a Prospective Study.
PG  - 2338-2344
LID - 10.1007/s11695-020-04471-x [doi]
AB  - PURPOSE: One anastomosis gastric bypass (OAGB) is a promising bariatric 
      procedure. We performed this study to evaluate the changes in a group of 
      inflammatory cytokines 12 months after OAGB. METHODS: A single-arm prospective 
      study was conducted on obese patients who underwent OAGB. The serum levels of the 
      following adipocytokines were monitored pre- and 12 months postoperatively: 
      adiponectin, leptin, interleukin 6 (IL-6), interleukin 8 (IL-8) levels, tumor 
      necrosis factor-alpha (TNF-alpha), serum amyloid A (SAA), high-sensitivity C-reactive 
      protein (hs-CRP), and monocyte chemotactic protein 1 (MCP-1). RESULTS: A total of 
      62 patients were included with a mean age of 43.9 +/- 6.8 years old. The serum 
      adiponectin increased significantly from 7.64 +/- 0.29 to 8.76 +/- 0.42 mug/mL 
      12 months after the operation (p < 0.001). hs-CRP and IL-6 decreased 
      significantly 12 months after the OAGB from 3323.35 +/- 643.4 ng/mL and 
      3.72 +/- 7.7 pg/mL to 1376.81 +/- 609.4 ng/mL and 3.64 +/- 6.9 pg/mL, respectively 
      (p < 0.001). The MCP-1 showed significant increase in its level after OAGB as 
      well (p = 0.014). In contrary, there were no significant changes in serum levels 
      of IL-8 (p = 0.12) and TNF-alpha (p = 0.84) 12 months after the operation. The 
      correlation analysis showed significant correlations between initial body mass 
      index (BMI) with serum adiponectin, IL-8, and serum SAA. CONCLUSION: OAGB can 
      significantly impact the inflammatory cytokine profile in obese patients with 
      possible subsequent protection from obesity-related comorbidities such as insulin 
      resistance, cardiovascular diseases, and certain cancers.
FAU - Salman, Mohamed Abdalla
AU  - Salman MA
AD  - General Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Abdallah, Ahmed
AU  - Abdallah A
AD  - General Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Mikhail, Hani Maurice Sabri
AU  - Mikhail HMS
AD  - General Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Abdelsalam, Ahmed
AU  - Abdelsalam A
AD  - General Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Ibrahim, Ayman Helmy
AU  - Ibrahim AH
AD  - General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, 
      Egypt.
FAU - Sultan, Ahmed Abd El Aal
AU  - Sultan AAEA
AUID- ORCID: 0000-0003-1097-2615
AD  - General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, 
      Egypt.
FAU - El-Ghobary, Mohamed
AU  - El-Ghobary M
AD  - Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, 
      Egypt.
FAU - Ismail, Amro Abdelaziz Mohammed
AU  - Ismail AAM
AD  - Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, 
      Egypt.
FAU - Abouelregal, Tarek Elsayed
AU  - Abouelregal TE
AD  - Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, 
      Egypt.
FAU - Omar, Mahmoud Gouda
AU  - Omar MG
AD  - Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, 
      Egypt.
FAU - AbdelAal, Alhoussein Alsayed
AU  - AbdelAal AA
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Shaaban, Hossam El-Din
AU  - Shaaban HE
AD  - National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
FAU - GabAllah, Ghada M K
AU  - GabAllah GMK
AD  - Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shibin 
      El Kom, Egypt.
FAU - Tourky, Mohamed
AU  - Tourky M
AD  - Alawi Tunsi, Mecca, Saudi Arabia.
FAU - Salman, Ahmed Abdallah
AU  - Salman AA
AUID- ORCID: 0000-0003-0026-0841
AD  - Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, 
      Egypt. awea844@gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Cytokines
MH  - *Gastric Bypass
MH  - Humans
MH  - Middle Aged
MH  - *Obesity, Morbid/surgery
MH  - Prospective Studies
MH  - Weight Loss
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Inflammatory Adipokines
OT  - One anastomosis gastric bypass
EDAT- 2020/02/12 06:00
MHDA- 2021/04/15 06:00
CRDT- 2020/02/12 06:00
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
AID - 10.1007/s11695-020-04471-x [pii]
AID - 10.1007/s11695-020-04471-x [doi]
PST - ppublish
SO  - Obes Surg. 2020 Jun;30(6):2338-2344. doi: 10.1007/s11695-020-04471-x.