PMID- 32043819
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20210110
IS  - 2051-3909 (Electronic)
IS  - 2051-3895 (Print)
IS  - 2051-3895 (Linking)
VI  - 67
IP  - 1
DP  - 2020 Mar
TI  - Parotid sparing in RapidPlan Oropharynx models: To split or not to split.
PG  - 80-86
LID - 10.1002/jmrs.376 [doi]
AB  - INTRODUCTION: Differences in knowledge and experience, patient anatomy and tumour 
      location and manipulation of inverse planning objectives and priorities will lead 
      to a variability in the quality of radiation planning. The aim of this study was 
      to investigate whether parotid glands should be treated as separate or combined 
      structures when using knowledge-based planning (KBP) to create oropharyngeal 
      plans, based on the dose they receive. METHOD: Two separate RapidPlan (RP) models 
      were created using the same 70 radical oropharyngeal patients. The 'separated 
      model' divided the parotids into ipsilateral and contralateral structures. The 
      'combined model' did not separate the parotids. The models were independently 
      validated using 20 patients not included in the models. The same dose constraints 
      and priorities were applied to planning target volumes (PTVs) and organs at risk 
      (OARs) for all plans. An auto-generated line objective and priority was applied 
      in both models, with parotid mean dose and V50 doses evaluated and compared. 
      RESULTS: Plans optimised using the combined model resulted in lower ipsilateral 
      mean doses and lower V50 doses in 80% and 75% of cases, respectively. Fifty-five 
      per cent of plans produced lower mean doses for the contralateral parotid when 
      optimised using the combined model, while lower V50 doses were evenly split 
      between the models. CONCLUSION: Combining the data for both parotids into one RP 
      model resulted in better ipsilateral parotid sparing. Results also suggest that a 
      combined parotid model will spare dose to the contralateral parotid; however, 
      further investigation is required to confirm these results.
CI  - (c) 2020 The Authors. Journal of Medical Radiation Sciences published by John Wiley 
      & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and 
      Radiation Therapy and New Zealand Institute of Medical Radiation Technology.
FAU - O'Toole, James
AU  - O'Toole J
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - Wu, Kenny
AU  - Wu K
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - Bromley, Regina
AU  - Bromley R
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - Stevens, Mark
AU  - Stevens M
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - Eade, Thomas
AU  - Eade T
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - van Gysen, Kirsten
AU  - van Gysen K
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
FAU - Atyeo, John
AU  - Atyeo J
AUID- ORCID: 0000-0003-4350-0294
AD  - Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North 
      Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200211
PL  - United States
TA  - J Med Radiat Sci
JT  - Journal of medical radiation sciences
JID - 101620352
SB  - IM
MH  - Humans
MH  - Organs at Risk
MH  - Oropharyngeal Neoplasms/*diagnostic imaging/radiotherapy
MH  - Oropharynx/*diagnostic imaging
MH  - Parotid Gland/*diagnostic imaging
MH  - *Patient-Specific Modeling
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
PMC - PMC7063248
OTO - NOTNLM
OT  - Head and Neck planning
OT  - Oropharynx model
OT  - RapidPlan
OT  - knowledge-based planning
OT  - parotid sparing
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/12 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/02/11
CRDT- 2020/02/12 06:00
PHST- 2019/08/26 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/12/12 00:00 [accepted]
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
PHST- 2020/02/11 00:00 [pmc-release]
AID - JMRS376 [pii]
AID - 10.1002/jmrs.376 [doi]
PST - ppublish
SO  - J Med Radiat Sci. 2020 Mar;67(1):80-86. doi: 10.1002/jmrs.376. Epub 2020 Feb 11.