PMID- 32044155
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1872-9096 (Electronic)
IS  - 0166-3542 (Linking)
VI  - 176
DP  - 2020 Apr
TI  - Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration.
PG  - 104720
LID - S0166-3542(19)30724-7 [pii]
LID - 10.1016/j.antiviral.2020.104720 [doi]
AB  - Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are members of the genus 
      Roseolovirus in the Betaherpesvirinae subfamily. HHV-6B infects humans in the 
      first years of life, has a seroprevalence of more than 90% and causes Roseola 
      Infantum, but less is known about HHV-6A. While most other herpesviruses maintain 
      their latent genome as a circular episome, HHV-6A and HHV-6B (HHV-6A/B) have been 
      shown to integrate their genome into the telomeres of infected cells. HHV-6A/B 
      can also integrate into the chromosomes of germ cells, resulting in individuals 
      carrying a copy of the virus genome in every nucleated cell of their bodies. This 
      review highlights our current understanding of HHV-6A/B integration and 
      reactivation as well as aspects that should be addressed in the future of this 
      relatively young research area. It forms part of an online symposium on the 
      prevention and therapy of DNA virus infections, dedicated to the memory of Mark 
      Prichard.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Aimola, Giulia
AU  - Aimola G
AD  - Institut fur Virologie, Freie Universitat Berlin, Robert von Ostertag-Strasse 
      7-13, 14163, Berlin, Germany.
FAU - Beythien, Georg
AU  - Beythien G
AD  - Institut fur Virologie, Freie Universitat Berlin, Robert von Ostertag-Strasse 
      7-13, 14163, Berlin, Germany.
FAU - Aswad, Amr
AU  - Aswad A
AD  - Institut fur Virologie, Freie Universitat Berlin, Robert von Ostertag-Strasse 
      7-13, 14163, Berlin, Germany.
FAU - Kaufer, Benedikt B
AU  - Kaufer BB
AD  - Institut fur Virologie, Freie Universitat Berlin, Robert von Ostertag-Strasse 
      7-13, 14163, Berlin, Germany. Electronic address: b.kaufer@fu-berlin.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200207
PL  - Netherlands
TA  - Antiviral Res
JT  - Antiviral research
JID - 8109699
RN  - 0 (DNA, Viral)
SB  - IM
MH  - *Chromosomes
MH  - DNA, Viral/*genetics
MH  - *Genome, Viral
MH  - Herpesvirus 6, Human/*genetics/pathogenicity
MH  - Humans
MH  - Telomere/genetics
MH  - Virus Integration/*genetics
OTO - NOTNLM
OT  - Germ line
OT  - Human herpesvirus 6
OT  - Integration
OT  - Telomeres
OT  - iciHHV-6
EDAT- 2020/02/12 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/02/12 06:00
PHST- 2019/12/17 00:00 [received]
PHST- 2020/01/21 00:00 [revised]
PHST- 2020/01/23 00:00 [accepted]
PHST- 2020/02/12 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/02/12 06:00 [entrez]
AID - S0166-3542(19)30724-7 [pii]
AID - 10.1016/j.antiviral.2020.104720 [doi]
PST - ppublish
SO  - Antiviral Res. 2020 Apr;176:104720. doi: 10.1016/j.antiviral.2020.104720. Epub 
      2020 Feb 7.