PMID- 32047527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2020
DP  - 2020
TI  - The Impact of Natural Product Dietary Supplements on Patients with Gout: A 
      Systematic Review and Meta-Analysis of Randomized Controlled Trials.
PG  - 7976130
LID - 10.1155/2020/7976130 [doi]
LID - 7976130
AB  - Natural product dietary supplements (NPDS) are frequently used for the treatment 
      of gout, but reliable efficacy and safety data are generally lacking or not well 
      organized to guide clinical decision making. This review aims to explore the 
      impacts of NPDS for patients with gout. An electronic literature search was 
      conducted to retrieve data published in English language from databases from 
      inception to August 14, 2019. Randomized controlled trials (RCTs) that compared 
      NPDS with or without placebo, diet modification, conventional pharmaceutics, or 
      the other Chinese medicine treatment for gout patients were included. Two authors 
      screened the articles, extracted the data, and assessed the risk of bias of each 
      included trial independently. Meta-analysis was performed using Review Manager 
      version 5.3.5. Results. Nine RCTS were enrolled in this review. The 
      methodological quality of the nine RCTs was poor. The study results showed that 
      in the majority of trials, NPDS demonstrated some degree of therapeutic efficacy 
      for joint swelling, pain, and activity limitation. In contradistinction, serum 
      uric acid (SUA) level (SMD -1.80, 95% CI: -4.45 to 0.86) (p > 0.05) and CRP 
      levels (N = 232; SMD, -0.26; 95% CI, -0.55 to 0.04) (p > 0.05) did not improve 
      significantly. The incidence of adverse events (AEs) was not lower in the 
      participants treated with NPDS (N = 750; RR, 0.47; 95% CI, 0.20-1.11) (p > 0.05). 
      Conclusion. Current existing evidence is not sufficient to provide clinical 
      guidance regarding the efficacy and safety of NPDS as a treatment for gout due to 
      poor trial quality and lack of standardized evaluation criteria. Larger and more 
      rigorously designed RCTs are needed in the future.
CI  - Copyright (c) 2020 Juan Yang et al.
FAU - Yang, Juan
AU  - Yang J
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
AD  - Department of Pain Medicine, Shenzhen Nanshan People's Hospital, Guangdong 
      Medical University, Shenzhen, Guangdong 518052, China.
FAU - Li, Guangxi
AU  - Li G
AUID- ORCID: 0000-0002-2234-9188
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, 
      China.
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Epidemiology and 
      Translational Research in Intensive Care, Rochester, MN 55905, USA.
FAU - Xiong, Donglin
AU  - Xiong D
AD  - Department of Pain Medicine, Shenzhen Nanshan People's Hospital, Guangdong 
      Medical University, Shenzhen, Guangdong 518052, China.
FAU - Chon, Tony Y
AU  - Chon TY
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Bauer, Brent A
AU  - Bauer BA
AUID- ORCID: 0000-0003-3453-6906
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200123
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC7003261
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/02/13 06:00
MHDA- 2020/02/13 06:01
PMCR- 2020/01/23
CRDT- 2020/02/13 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/12/27 00:00 [accepted]
PHST- 2020/02/13 06:00 [entrez]
PHST- 2020/02/13 06:00 [pubmed]
PHST- 2020/02/13 06:01 [medline]
PHST- 2020/01/23 00:00 [pmc-release]
AID - 10.1155/2020/7976130 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2020 Jan 23;2020:7976130. doi: 
      10.1155/2020/7976130. eCollection 2020.