PMID- 32047901 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20210320 IS - 1464-3502 (Electronic) IS - 0735-0414 (Print) IS - 0735-0414 (Linking) VI - 55 IP - 2 DP - 2020 Mar 19 TI - Lower Serum Magnesium Concentrations are associated With Specific Heavy Drinking Markers, Pro-Inflammatory Response and Early-Stage Alcohol-associated Liver Injury section sign. PG - 164-170 LID - 10.1093/alcalc/agaa001 [doi] AB - AIM: Chronic heavy alcohol intake frequently causes liver inflammation/injury, and altered mineral metabolism may be involved in this liver pathology. In this study, we evaluated the association of heavy drinking, changes in serum magnesium levels and biochemical evidence of liver injury in alcohol-use-disorder (AUD) patients who had no clinical signs or symptoms of liver injury. We also aimed to identify any sex-based differences in patients with mild or no biochemical evidence of liver injury induced by heavy drinking. METHODS: 114 heavy drinking alcohol-dependent (AD) female and male patients aged 21-65 years without clinical manifestations of liver injury, who were admitted to an alcohol treatment program, were grouped by alanine aminotransaminase (ALT) levels: 40 IU/L as mild liver injury (GR.2). Patients were actively drinking until the day of admission. Comprehensive metabolic biochemistry results, fatty acid panel, serum magnesium and drinking history data were collected at admission; and study-specific measures were evaluated. RESULTS: In all AD patients, lower magnesium was significantly associated with the heavy drinking marker and heavy drinking days past 90 days (HDD90). A lower serum magnesium concentration was observed in AD patients with mild liver injury. Females of both groups had mean levels of magnesium in the deficient range. A clinically significant drop in magnesium levels was observed only in the GR.2 (mild liver injury) male AD patients. Females showed a significant association between low magnesium levels and the omega6:omega3 polyunsaturated fatty acids (PUFAs) ratio. CONCLUSIONS: Specific heavy drinking markers showed an association with lower magnesium levels. Low serum magnesium levels are common in subjects with AUD and appear to be associated with the onset of liver injury. CI - Published by Oxford University Press 2020. FAU - Vatsalya, Vatsalya AU - Vatsalya V AD - Department of Medicine, University of Louisville, Louisville, KY, USA. AD - Robley Rex VA Medical Center, Louisville, KY, USA. AD - Hepatology and Toxicology Center, University of Louisville, Louisville, KY, USA. AD - Alcohol Research Center, University of Louisville, Louisville, KY, USA. FAU - Gala, Khushboo S AU - Gala KS AD - Department of Medicine, University of Louisville, Louisville, KY, USA. FAU - Mishra, Maithili AU - Mishra M AD - Department of Computer Engineering, University of Southern Florida, Tampa, FL, USA. FAU - Schwandt, Melanie L AU - Schwandt ML AD - National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. FAU - Umhau, John AU - Umhau J AD - National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. FAU - Cave, Matthew C AU - Cave MC AD - Department of Medicine, University of Louisville, Louisville, KY, USA. AD - Robley Rex VA Medical Center, Louisville, KY, USA. AD - Hepatology and Toxicology Center, University of Louisville, Louisville, KY, USA. AD - Alcohol Research Center, University of Louisville, Louisville, KY, USA. AD - Department of Pharmacology and Toxicology, Louisville, KY, USA. FAU - Parajuli, Dipendra AU - Parajuli D AD - Department of Medicine, University of Louisville, Louisville, KY, USA. AD - Robley Rex VA Medical Center, Louisville, KY, USA. FAU - Ramchandani, Vijay A AU - Ramchandani VA AD - National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. FAU - McClain, Craig J AU - McClain CJ AD - Department of Medicine, University of Louisville, Louisville, KY, USA. AD - Robley Rex VA Medical Center, Louisville, KY, USA. AD - Hepatology and Toxicology Center, University of Louisville, Louisville, KY, USA. AD - Alcohol Research Center, University of Louisville, Louisville, KY, USA. AD - Department of Pharmacology and Toxicology, Louisville, KY, USA. LA - eng GR - P50 AA024337/AA/NIAAA NIH HHS/United States GR - U01 AA026936/AA/NIAAA NIH HHS/United States GR - U01 AA026980/AA/NIAAA NIH HHS/United States GR - R01 AA023681/AA/NIAAA NIH HHS/United States GR - I01 BX002996/BX/BLRD VA/United States GR - Z99 AA999999/ImNIH/Intramural NIH HHS/United States GR - P20 GM113226/GM/NIGMS NIH HHS/United States PT - Journal Article PL - England TA - Alcohol Alcohol JT - Alcohol and alcoholism (Oxford, Oxfordshire) JID - 8310684 RN - 0 (Biomarkers) RN - 0 (Fatty Acids, Unsaturated) RN - EC 2.6.1.2 (Alanine Transaminase) RN - I38ZP9992A (Magnesium) SB - IM MH - Adult MH - Aged MH - Alanine Transaminase/*blood MH - Alcohol Drinking/*blood MH - Alcoholism/complications MH - Biomarkers/blood MH - Fatty Acids, Unsaturated/*blood MH - Female MH - Humans MH - Liver Diseases, Alcoholic/*blood/complications MH - Magnesium/*blood MH - Male MH - Middle Aged MH - Sex Factors MH - Young Adult PMC - PMC7082490 EDAT- 2020/02/13 06:00 MHDA- 2020/12/22 06:00 PMCR- 2021/03/19 CRDT- 2020/02/13 06:00 PHST- 2019/04/17 00:00 [received] PHST- 2019/12/16 00:00 [revised] PHST- 2020/01/23 00:00 [accepted] PHST- 2020/02/13 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/02/13 06:00 [entrez] PHST- 2021/03/19 00:00 [pmc-release] AID - 5734241 [pii] AID - agaa001 [pii] AID - 10.1093/alcalc/agaa001 [doi] PST - ppublish SO - Alcohol Alcohol. 2020 Mar 19;55(2):164-170. doi: 10.1093/alcalc/agaa001.