PMID- 32048436
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 21
IP  - 5
DP  - 2020 May
TI  - Foetal and childhood exposure to famine and the risks of cardiometabolic 
      conditions in adulthood: A systematic review and meta-analysis of observational 
      studies.
PG  - e12981
LID - 10.1111/obr.12981 [doi]
AB  - A systematic review and meta-analysis of observational studies was performed to 
      provide a deeper understanding of the associations between foetal and childhood 
      exposure to famine and the risks of type 2 diabetes mellitus (T2DM), metabolic 
      syndrome, hypertension, hyperglycaemia, dyslipidaemia, obesity, overweight, 
      coronary heart disease, stroke, and nonalcoholic fatty liver disease (NAFLD) in 
      adulthood. Both foetal and childhood exposure to famine were positively 
      associated with the risks of T2DM (foetal exposure: RR 1.37, 95% CI, 1.23-1.52; 
      childhood exposure: RR 1.33, 95% CI, 1.08-1.64), metabolic syndrome (RR 1.26, 95% 
      CI, 1.07-1.50; RR 1.24, 95% CI, 1.13-1.35), hypertension (RR 1.30, 95% CI, 
      1.07-1.57; RR 1.33, 95% CI, 1.02-1.74), hyperglycaemia (RR 1.27, 95% CI, 
      1.11-1.45; RR 1.25, 95% CI, 1.10-1.42), dyslipidaemia (RR 1.48, 95% CI, 
      1.33-1.66; RR 1.27, 95% CI, 1.12-1.45), obesity (RR 1.19, 95% CI, 1.02-1.39; RR 
      1.13, 95% CI, 1.00-1.28), overweight (RR 1.17, 95% CI, 1.07-1.29; RR 1.07, 95% 
      CI, 1.00-1.14), coronary heart disease (RR 1.22, 95% CI, 1.00-1.51; RR 1.21, 95% 
      CI, 1.09-1.35), and moderate-to-severe NAFLD (RR 1.66, 95% CI, 1.07-2.57; RR 
      1.68, 95% CI, 1.41-1.99) in adulthood. No association was observed for the risks 
      of stroke or mild NAFLD. Adjustments for age, alcohol, smoking, body mass index, 
      and physical activity nullified some associations. The associations were 
      generally stronger in women than in men. In summary, foetal and childhood 
      exposure to famine may confer greater risks of developing certain cardiometabolic 
      conditions in adulthood, particularly in women. The extent to which risks for 
      cardiometabolic conditions are associated with early-life famine appears to be 
      determined by certain factors in adulthood.
CI  - (c) 2020 World Obesity Federation.
FAU - Hidayat, Khemayanto
AU  - Hidayat K
AUID- ORCID: 0000-0002-4095-6969
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Soochow University, Suzhou, China.
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
FAU - Du, Xuan
AU  - Du X
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Soochow University, Suzhou, China.
FAU - Shi, Bi-Min
AU  - Shi BM
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Soochow University, Suzhou, China.
FAU - Qin, Li-Qiang
AU  - Qin LQ
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20200211
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the 
      Study of Obesity
JID - 100897395
SB  - IM
MH  - Adult
MH  - *Cardiometabolic Risk Factors
MH  - Cardiovascular Diseases/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology
MH  - Famine/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Metabolic Syndrome/epidemiology
MH  - Observational Studies as Topic
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Risk Factors
OTO - NOTNLM
OT  - childhood
OT  - developmental origins
OT  - diabetes mellitus
OT  - famine
OT  - hypertension
OT  - lipids
OT  - metabolic syndrome
OT  - obesity
OT  - prenatal
OT  - undernutrition
EDAT- 2020/02/13 06:00
MHDA- 2021/04/02 06:00
CRDT- 2020/02/13 06:00
PHST- 2019/10/17 00:00 [received]
PHST- 2019/11/11 00:00 [accepted]
PHST- 2020/02/13 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2020/02/13 06:00 [entrez]
AID - 10.1111/obr.12981 [doi]
PST - ppublish
SO  - Obes Rev. 2020 May;21(5):e12981. doi: 10.1111/obr.12981. Epub 2020 Feb 11.