PMID- 32050320
OWN - NLM
STAT- MEDLINE
DCOM- 20200403
LR  - 20200403
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 244
DP  - 2020 Apr
TI  - New insight into the mechanism of POP-induced obesity: Evidence from DDE-altered 
      microbiota.
PG  - 125123
LID - S0045-6535(19)32362-8 [pii]
LID - 10.1016/j.chemosphere.2019.125123 [doi]
AB  - Although epidemiological studies demonstrate that persistent organic pollutants 
      (POPs) could lead to metabolic syndrome, the mechanism has remained unclear. The 
      dysbiosis of gut microbiota and the lipid metabolome have been put forward in the 
      pathophysiology of metabolic syndrome. In this study, we used 
      dichlorodiphenyldichloroethylene (DDE) as an example to study the effects of 
      POP-impaired microbial composition and metabolome homeostasis on metabolic 
      syndrome. The results showed that DDE exposure increased body weight and fat 
      content and impaired glucose homeostasis. Further investigation revealed that DDE 
      induced gut dysbiosis as indicated by an increased Firmicutes-to-Bacteroidetes 
      ratio, which may impact energy harvest efficiency. Meanwhile, the plasma lipid 
      metabolome profile was significantly altered by DDE. Furthermore, 
      phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and 
      triacylglycerol were identified as key metabolites affected by DDE treatment, and 
      these altered lipid metabolites were highly correlated with changed microbiota 
      composition. This study provides novel insight into the underlying mechanism of 
      POP-induced obesity and diabetes, pointing to gut microbiota as one of the 
      targets.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Liang, Yiran
AU  - Liang Y
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China; College of Chemistry and Biological Engineering, 
      University of Science and Technology Beijing, No. 30, Xueyuan Road, Beijing, 
      100083, PR China.
FAU - Liu, Donghui
AU  - Liu D
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China.
FAU - Zhan, Jing
AU  - Zhan J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China.
FAU - Luo, Mai
AU  - Luo M
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China.
FAU - Han, Jiajun
AU  - Han J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China.
FAU - Wang, Peng
AU  - Wang P
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China.
FAU - Zhou, Zhiqiang
AU  - Zhou Z
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, 
      Beijing, 100193, PR China. Electronic address: zqzhou@cau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191016
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
SB  - IM
MH  - Animals
MH  - Dichlorodiphenyl Dichloroethylene/*adverse effects
MH  - Dysbiosis/microbiology
MH  - Environmental Pollutants/adverse effects
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Humans
MH  - Lipid Metabolism/drug effects
MH  - Metabolic Syndrome/*etiology
MH  - Metabolome/drug effects
MH  - Obesity/*chemically induced/metabolism
OTO - NOTNLM
OT  - DDE
OT  - Lipid metabolome
OT  - Metabolic syndrome
OT  - Microbiota
COIS- Declaration of competing interest The authors have no conflicts of interest to 
      declare.
EDAT- 2020/02/14 06:00
MHDA- 2020/04/04 06:00
CRDT- 2020/02/14 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/09/27 00:00 [revised]
PHST- 2019/10/13 00:00 [accepted]
PHST- 2020/02/14 06:00 [entrez]
PHST- 2020/02/14 06:00 [pubmed]
PHST- 2020/04/04 06:00 [medline]
AID - S0045-6535(19)32362-8 [pii]
AID - 10.1016/j.chemosphere.2019.125123 [doi]
PST - ppublish
SO  - Chemosphere. 2020 Apr;244:125123. doi: 10.1016/j.chemosphere.2019.125123. Epub 
      2019 Oct 16.