PMID- 32053409
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20221207
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 130
IP  - 11
DP  - 2020 Nov
TI  - Analysis of risk factors for depression in Alzheimer's disease patients.
PG  - 1136-1141
LID - 10.1080/00207454.2020.1730369 [doi]
AB  - Purpose: Depression, which affects about 52% of Alzheimer's disease (AD) 
      patients, can worsen cognitive impairment and increase mortality and suicide 
      rates. We hope to provide clinical evidence for the prevention and treatment of 
      depression in AD patients by investigating related risk factors of depression in 
      AD patients.Methods: 158 AD inpatients of the Department of Neurology, Daping 
      Hospital from September 2017 to March 2019 were enrolled. General information, 
      laboratory tests, cognitive and emotional function assessments of the inpatients 
      were collected. Logistic regression was used to analyze the risk factors of 
      depression in AD patients, and the relationship between 17 Hamilton depression 
      scale scores and HbA1c levels in AD patients was further analyzed.Results: The 
      prevalence of age, gender, hypertension, hyperlipidemia, Type 2 diabetes mellitus 
      (T2DM), and white matter lesions (WML) in the AD with depression group was 
      significantly different from without depression group. Hypertension, T2DM, and 
      WML are independent risk factors for depression in AD patients. The depression 
      scores of AD patients with HbA1c>6.5% were significantly higher than AD patients 
      with HbA1c </= 6.5%, and there were significant difference in depression scale 
      scores between using anti-diabetes drugs group and not using anti-diabetes drugs 
      group whose HbA1c level is >6.5%, while no difference in depression scores 
      between using anti-diabetes drugs group and not using anti-diabetes drugs group 
      whose HbA1c level is </=6.5%.Conclusion: T2DM is an independent risk factor for AD 
      patients with depression. Increased HbA1c levels aggravate depression in AD 
      patients, and controlling HbA1c levels and anti-diabetes drugs can reduce the 
      severity of depression in AD patients.
FAU - Yang, Hai
AU  - Yang H
AD  - Department of Neurology, Daping Hospital, Army Military Medical University, 
      Chongqing, China.
FAU - Hong, Wenjuan
AU  - Hong W
AD  - Graduate School of Bengbu Medical College, Bengbu City, China.
FAU - Chen, Le
AU  - Chen L
AD  - Graduate School of Bengbu Medical College, Bengbu City, China.
FAU - Tao, Yong
AU  - Tao Y
AD  - Department of Neurology, Daping Hospital, Army Military Medical University, 
      Chongqing, China.
FAU - Peng, Zeyan
AU  - Peng Z
AD  - Department of Neurology, Daping Hospital, Army Military Medical University, 
      Chongqing, China.
FAU - Zhou, Huadong
AU  - Zhou H
AD  - Department of Neurology, Daping Hospital, Army Military Medical University, 
      Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20200227
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/blood/*epidemiology
MH  - China/epidemiology
MH  - Comorbidity
MH  - Depressive Disorder/blood/drug therapy/*epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications/drug therapy/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - anti-diabetes drugs
OT  - depression
OT  - glycosylated hemoglobin
EDAT- 2020/02/14 06:00
MHDA- 2021/07/30 06:00
CRDT- 2020/02/14 06:00
PHST- 2020/02/14 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2020/02/14 06:00 [entrez]
AID - 10.1080/00207454.2020.1730369 [doi]
PST - ppublish
SO  - Int J Neurosci. 2020 Nov;130(11):1136-1141. doi: 10.1080/00207454.2020.1730369. 
      Epub 2020 Feb 27.