PMID- 32053642
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20200603
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 2
DP  - 2020
TI  - Intake frequency of vegetables or seafoods negatively correlates with disease 
      activity of rheumatoid arthritis.
PG  - e0228852
LID - 10.1371/journal.pone.0228852 [doi]
LID - e0228852
AB  - OBJECTIVE: To clarify the relationship between dietary habit and disease activity 
      of rheumatoid arthritis (RA). METHODS: This study enrolled RA patients who met 
      the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid 
      Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency 
      questionnaire (FFQ) was taken for the measurement of dietary habit in a 
      single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management 
      Alliance: KURAMA) in 2015. The disease activities of RA using the Disease 
      Activity Score calculated based on the erythrocyte sedimentation rate 
      (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment 
      Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use 
      of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid 
      factor, anti-cyclic citrullinated antibody, and body mass index were also 
      examined. All of them were combined and statistically analyzed. RESULTS: 441 RA 
      patients (81% women; mean age 65 years; mean disease duration 15 years) were 
      enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the 
      erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed 
      that intake frequency of vegetables had a statistically significant negative 
      correlation with disease activity markers, such as DAS28-ESR (rho = -0.11, p<0.01), 
      Simplified Disease Activity Index (SDAI) (rho = -0.16, p<0.001), matrix 
      metalloproteinase-3 (MMP-3) (rho = -0.21, p<0.0001), and Health Assessment 
      Questionnaire (HAQ) (rho = -0.13, p<0.01). Factor analysis with varimax rotation 
      was done to simplify the relevance of disease activity to various food items. 22 
      foods were categorized into five dietary patterns: "seafoods", 
      "vegetables/fruits", "meats/fried foods", "snacks", and "processed foods". The 
      multivariate analysis adjusted for clinically significant confounders showed that 
      "seafoods" had statistically significant negative correlations with DAS28-ESR (beta 
      = -0.15, p<0.01), SDAI (beta = -0.18, p<0.001), MMP-3 (beta = -0.15, p<0.01), and HAQ 
      (beta = -0.24, p<0.0001). "Vegetables/fruits" had statistically significant negative 
      correlations with SDAI (beta = -0.11 p<0.05), MMP-3 (beta = -0.12, p<0.01), and HAQ (beta 
      = -0.11, p<0.05). CONCLUSIONS: These results suggest that high intake frequency 
      of vegetables/fruits and/or seafoods might correlate with low disease activity.
FAU - Murakami, Isao
AU  - Murakami I
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Murakami, Kosaku
AU  - Murakami K
AUID- ORCID: 0000-0001-5981-4648
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Hashimoto, Motomu
AU  - Hashimoto M
AD  - Department of the Advanced Medicine for Rheumatic Diseases, Graduate School of 
      Medicine, Kyoto University, Kyoto, Japan.
FAU - Tanaka, Masao
AU  - Tanaka M
AD  - Department of the Advanced Medicine for Rheumatic Diseases, Graduate School of 
      Medicine, Kyoto University, Kyoto, Japan.
FAU - Ito, Hiromu
AU  - Ito H
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Fujii, Takao
AU  - Fujii T
AD  - Department of Rheumatology and Clinical Immunology, Wakayama Medical University, 
      Wakayama, Japan.
FAU - Torii, Mie
AU  - Torii M
AD  - Department of Human Health Sciences, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Ikeda, Kaori
AU  - Ikeda K
AD  - Department of Diabetes, Endocrinology, and Nutrition, Graduate School of 
      Medicine, Kyoto University, Kyoto, Japan.
FAU - Kuwabara, Akiko
AU  - Kuwabara A
AD  - Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka 
      Prefecture University, Osaka, Japan.
FAU - Tanaka, Kiyoshi
AU  - Tanaka K
AD  - Department of Faculty of Nutrition, Kobe Gakuin University, Hyogo, Japan.
FAU - Yoshida, Akiko
AU  - Yoshida A
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Akizuki, Shuji
AU  - Akizuki S
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Nakashima, Ran
AU  - Nakashima R
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Yoshifuji, Hajime
AU  - Yoshifuji H
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Ohmura, Koichiro
AU  - Ohmura K
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Usui, Takashi
AU  - Usui T
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Morita, Satoshi
AU  - Morita S
AD  - Depatment of Biomedical Statistics and Bioinformatics, Kyoto University, Kyoto, 
      Japan.
FAU - Mimori, Tsuneyo
AU  - Mimori T
AD  - Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200213
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/*drug therapy/*metabolism
MH  - Blood Sedimentation/drug effects
MH  - Cohort Studies
MH  - Feeding Behavior/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/analysis/blood
MH  - Middle Aged
MH  - Nutrients/*therapeutic use
MH  - Seafood/analysis
MH  - Severity of Illness Index
MH  - Vegetables/metabolism
PMC - PMC7018088
COIS- I.M. has declared no conflicts of interests. K.M. has received speaking fees, 
      and/or consulting fees from Eisai Co. Ltd. M.H. received research grant and/or 
      speaker fee from Astellas, Eisai, Tanabe-Mitsubishi, and Brystol-Meyers. T. M. 
      received research grants and/or speaking fees from Asahikasei Pharma Corp., 
      Astellas Pharma Inc., AYUMI Pharmaceutical Corp., Bristol-Myers Squibb, Chugai 
      Pharmaceutical Co, Ltd., Diaichi-Sankyo Co.,Ltd., Eisai Co., Ltd., Eli Lilly 
      Japan K.K., Mitsubishi-Tanabe Pharma Co., Pfizer Japan Inc., Sanofi K.K. and 
      Takeda Pharmaceutical Co., Ltd.. These companies had no role in the design of the 
      study, the collection or analysis of the data, the writing of the manuscript or 
      decision to submit the manuscript for the publication. This does not alter our 
      adherence to PLOS ONE policies on sharing data and materials.
EDAT- 2020/02/14 06:00
MHDA- 2020/06/04 06:00
PMCR- 2020/02/13
CRDT- 2020/02/14 06:00
PHST- 2019/11/13 00:00 [received]
PHST- 2020/01/23 00:00 [accepted]
PHST- 2020/02/14 06:00 [entrez]
PHST- 2020/02/14 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
PHST- 2020/02/13 00:00 [pmc-release]
AID - PONE-D-19-31605 [pii]
AID - 10.1371/journal.pone.0228852 [doi]
PST - epublish
SO  - PLoS One. 2020 Feb 13;15(2):e0228852. doi: 10.1371/journal.pone.0228852. 
      eCollection 2020.