PMID- 32053943
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 4
DP  - 2020 Feb 11
TI  - Assessment of the Phenolic Profiles, Hypoglycemic Activity, and Molecular 
      Mechanism of Different Highland Barley (Hordeum vulgare L.) Varieties.
LID - 10.3390/ijms21041175 [doi]
LID - 1175
AB  - The phenolic profiles, hypoglycemic activity, and molecular mechanism of the 
      effect on type 2 diabetes mellitus (T2DM) of four highland barley varieties were 
      investigated in the present study. The fundamental phenolics in highland barley 
      were ferulic acid, naringin, and catechin, which mainly existed in bound form. 
      These varieties showed favorable hypoglycemic activity via inhibition of 
      alpha-glucosidase and alpha-amylase activities, enhancement of glucose consumption, 
      glycogen accumulation and glycogen synthase 2 (GYS2) activity, and 
      down-regulation of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate 
      carboxykinase (PEPCK) activities. Specifically, ZQ320 variety exhibited the 
      strongest hypoglycemic activity compared to the other varieties. Highland barley 
      phenolics could inhibit gluconeogenesis and motivate glycogen synthesis via 
      down-regulating the gene expression of G6Pase, PEPCK, and glycogen synthase 
      kinase 3beta (GSK3beta), while activating the expression of insulin receptor 
      substrate-1 (IRS-1), phosphatidylinositol 3 kinase (PI3K), serine/threonine 
      kinase (Akt), GYS2, and glucose transporter type 4 (GLUT4). Therefore, phenolics 
      from highland barley could be served as suitable candidates for therapeutic agent 
      in T2DM to improve human health.
FAU - Deng, Na
AU  - Deng N
AD  - Overseas Expertise Introduction Center for Discipline Innovation of Food 
      Nutrition and Human Health (111 Center), School of Food Science and Engineering, 
      South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
FAU - Zheng, Bisheng
AU  - Zheng B
AD  - Overseas Expertise Introduction Center for Discipline Innovation of Food 
      Nutrition and Human Health (111 Center), School of Food Science and Engineering, 
      South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
AD  - Guangdong ERA Food & Life Health Research Institute, Guangzhou 510670, China.
FAU - Li, Tong
AU  - Li T
AD  - Department of Food Science, Cornell University, Ithaca, NY 14853, USA.
FAU - Liu, Rui Hai
AU  - Liu RH
AD  - Department of Food Science, Cornell University, Ithaca, NY 14853, USA.
LA  - eng
GR  - B17018/111 Project/
PT  - Journal Article
DEP - 20200211
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Phenols)
RN  - EC 3.2.1.1 (alpha-Amylases)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Gluconeogenesis/drug effects
MH  - Glucose/metabolism
MH  - Glycoside Hydrolase Inhibitors/chemistry/pharmacology
MH  - Hep G2 Cells
MH  - Hordeum/*chemistry
MH  - Humans
MH  - Hypoglycemic Agents/*chemistry/*pharmacology
MH  - Phenols/*chemistry/*pharmacology
MH  - alpha-Amylases/antagonists & inhibitors/metabolism
MH  - alpha-Glucosidases/metabolism
PMC - PMC7072826
OTO - NOTNLM
OT  - highland barley
OT  - hypoglycemic activity
OT  - molecular mechanism
OT  - phenolic profiles
COIS- The authors have no conflict of interest to declare.
EDAT- 2020/02/15 06:00
MHDA- 2020/11/21 06:00
PMCR- 2020/02/01
CRDT- 2020/02/15 06:00
PHST- 2019/12/31 00:00 [received]
PHST- 2020/02/03 00:00 [revised]
PHST- 2020/02/10 00:00 [accepted]
PHST- 2020/02/15 06:00 [entrez]
PHST- 2020/02/15 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - ijms21041175 [pii]
AID - ijms-21-01175 [pii]
AID - 10.3390/ijms21041175 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Feb 11;21(4):1175. doi: 10.3390/ijms21041175.