PMID- 32054426
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 2214-6075 (Electronic)
IS  - 0377-5291 (Linking)
VI  - 39
IP  - 1
DP  - 2019 Dec
TI  - Effect of scaling and root planing on level of immunoglobulin E and 
      immunoglobulin G(4) in children with gingivitis and house-dust mite allergy: A 
      pilot randomised controlled trial.
PG  - 21-31
LID - 10.1142/S2214607519500020 [doi]
AB  - Background and Objective: There is a pressing need for developing innovative 
      strategies to prevent allergic diseases among children. As house-dust mite (HDM) 
      allergy is often seen in children with gingivitis, strategies should be derived 
      from a conceptual framework of allergen elimination and pathogen eradication; one 
      such strategy is dental scaling and root planing (SRP) to remove dental plaque 
      and periodontal pathogens. The study aimed to evaluate the beneficial effects of 
      comprehensive 6-months dental SRP to reduce the level of immunoglobulin E (IgE) 
      and immunoglobulin G(4) (IgG(4)) in children with gingivitis and HDM allergy. IgE 
      and IgG(4), whose production is controlled mainly by Th-2 cells and B cells, are 
      proven biomarkers for atopic inflammatory responses. Methods: The present study 
      conducted a non-blinded randomised controlled trial with superiority design. A 
      total of 10 subjects (age range 6-16 years) with gingivitis and positive 
      skin-prick test to HDM from Pediatric Allergy Outpatient Clinic, Dr. Soetomo 
      General Hospital were enrolled in the present study. Of the 10 subjects, only 
      five received dental SRP. We further evaluated total serum IgE and IgG(4) level 
      before and 6 months after treatment. Results and Discussion: Subjects in the 
      standard treatment group showed a slight decrease in the IgE level ([Formula: see 
      text]) but no change in the IgG(4) level ([Formula: see text]), while subjects in 
      the intervention group showed a significant decrease in IgE ([Formula: see text]) 
      and IgG(4) levels ([Formula: see text]). Conclusion: The study results suggest 
      that 6-month comprehensive dental scaling combined with root planing may help to 
      reduce IgE and IgG(4) levels in children with gingivitis and HDM allergy. 
      Furthermore, untreated or undertreated gingivitis is often associated with 
      worsening allergic manifestation and thus should be avoided. Trial Registration: 
      ISRCTN31416107, retrospectively registered on 17 April 2018.
FAU - Nelwan, Sindy Cornelia
AU  - Nelwan SC
AUID- ORCID: 0000-0001-7829-6524
AD  - Department of Pediatric Dentistry, Universitas Airlangga, Surabaya, 60135, 
      Indonesia.
FAU - Nugraha, Ricardo Adrian
AU  - Nugraha RA
AUID- ORCID: 0000-0003-0648-0829
AD  - Department of Medicine, Universitas Airlangga, Surabaya, 60135, Indonesia.
FAU - Endaryanto, Anang
AU  - Endaryanto A
AUID- ORCID: 0000-0002-6020-2136
AD  - Department of Child Health, Universitas Airlangga, Surabaya, 60135, Indonesia.
FAU - Dewi, Frisma
AU  - Dewi F
AD  - Department of Pediatric Dentistry, Universitas Airlangga, Surabaya, 60135, 
      Indonesia.
FAU - Nuraini, Prawati
AU  - Nuraini P
AD  - Department of Pediatric Dentistry, Universitas Airlangga, Surabaya, 60135, 
      Indonesia.
FAU - Tedjosasongko, Udijanto
AU  - Tedjosasongko U
AUID- ORCID: 0000-0003-3875-7415
AD  - Department of Pediatric Dentistry, Universitas Airlangga, Surabaya, 60135, 
      Indonesia.
FAU - Utomo, Daniel Haryono
AU  - Utomo DH
AD  - Department of Orthodontics, Universitas Airlangga, Surabaya, 60135, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200214
PL  - Singapore
TA  - Singapore Dent J
JT  - Singapore dental journal
JID - 7513690
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Dust)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - Adolescent
MH  - Animals
MH  - Antigens, Dermatophagoides
MH  - Child
MH  - Dental Scaling
MH  - Dust
MH  - *Gingivitis/prevention & control
MH  - Humans
MH  - *Hypersensitivity/therapy
MH  - Immunoglobulin E
MH  - Immunoglobulin G
MH  - *Mites
MH  - Pilot Projects
MH  - Root Planing
OTO - NOTNLM
OT  - Dental scaling
OT  - Gingivitis
OT  - House-dust mite
OT  - Immunoglobulin E
OT  - Root planing
EDAT- 2020/02/15 06:00
MHDA- 2021/06/01 06:00
CRDT- 2020/02/15 06:00
PHST- 2020/02/15 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
PHST- 2020/02/15 06:00 [entrez]
AID - 10.1142/S2214607519500020 [doi]
PST - ppublish
SO  - Singapore Dent J. 2019 Dec;39(1):21-31. doi: 10.1142/S2214607519500020. Epub 2020 
      Feb 14.