PMID- 32055117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jan-Feb
TI  - Apomorphine: The Initial Indian Experience in Relation to Response Tests and 
      Pumps.
PG  - 20-24
LID - 10.4103/aian.AIAN_428_19 [doi]
AB  - BACKGROUND: Apomorphine is an option for continuous dopaminergic therapy in 
      Parkinson's disease (PD). However, its effects in varied populations are limited 
      due to its availability. OBJECTIVE: To assess the efficacy and outcomes of 
      apomorphine in Indian patients. MATERIALS AND METHODS: Retrospective analysis of 
      PD patients who underwent apomorphine response test (ART), along with the subset, 
      who went on to apomorphine pumps. RESULTS: Twenty-nine confirmed PD patients 
      underwent ART and all PD patients showed good clinical response. 19 subjects 
      developed adverse events which included: nausea (n-15, 51.7%), vomiting (n-10, 
      34.4%), sleepiness (n-08; 27.5%), yawning (n-07, 24.1%), postural hypotension 
      (n-03, 10.3%), dizziness (n-03, 10.3%), and profuse sweating (n-01, 3.4%). 
      Apomorphine pumps were initiated in six subjects, with significant clinical 
      improvement. Adverse events on pump included subcutaneous nodules, nausea, 
      hypersexuality. Two among them subsequently discontinued the pump primarily due 
      to financial constraints. CONCLUSIONS: Apomorphine adds up to the armamentarium 
      for treatment of PD patients in India with good clinical responses.
CI  - Copyright: (c) 2006-2019 Annals of Indian Academy of Neurology.
FAU - Prashanth, L K
AU  - Prashanth LK
AD  - Center for Parkinson's Disease and Movement Disorders Clinic, Bengaluru, 
      Karnataka, India.
AD  - Department of Neurology, Institute of Neurosciences, Vikram Hospitals, Bengaluru, 
      Karnataka, India.
AD  - Parkinson's Disease and Movement Disorders Clinic, Bengaluru, Karnataka, India.
FAU - Jaychandran, R
AU  - Jaychandran R
AD  - Department of Neurology, Institute of Neurosciences, Vikram Hospitals, Bengaluru, 
      Karnataka, India.
FAU - Seetharam, Raghavendra
AU  - Seetharam R
AD  - Department of Neurology, Institute of Neurosciences, Vikram Hospitals, Bengaluru, 
      Karnataka, India.
FAU - Iyer, Rajesh B
AU  - Iyer RB
AD  - Department of Neurology, Institute of Neurosciences, Vikram Hospitals, Bengaluru, 
      Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20191219
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC7001430
OTO - NOTNLM
OT  - Adverse effects
OT  - India
OT  - apomorphine pumps
OT  - apomorphine response test
COIS- There are no conflicts of interest.
EDAT- 2020/02/15 06:00
MHDA- 2020/02/15 06:01
PMCR- 2020/01/01
CRDT- 2020/02/15 06:00
PHST- 2019/08/11 00:00 [received]
PHST- 2019/08/22 00:00 [revised]
PHST- 2019/09/15 00:00 [accepted]
PHST- 2020/02/15 06:00 [entrez]
PHST- 2020/02/15 06:00 [pubmed]
PHST- 2020/02/15 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - AIAN-23-20 [pii]
AID - 10.4103/aian.AIAN_428_19 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2020 Jan-Feb;23(1):20-24. doi: 10.4103/aian.AIAN_428_19. 
      Epub 2019 Dec 19.