PMID- 32055119
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jan-Feb
TI  - MuSK (Muscle Specific Kinase) Positive Myasthenia: Grave Prognosis or Undue 
      Prejudice?
PG  - 32-37
LID - 10.4103/aian.AIAN_302_19 [doi]
AB  - OBJECTIVES: Patients with muscle-specific kinase (MuSK)-positive myasthenia are 
      generally considered to have a grave prognosis. We present our experience of 
      patients with myasthenia with different antibody status. This is followed by a 
      short discourse on previous studies and the current view on MuSK-positive 
      myasthenia, focusing on the associated prejudice. MATERIALS AND METHODS: This 
      study compares 23 patients with MuSK-positive myasthenia with 55 patients with 
      acetylcholine receptor-positive myasthenia and 9 patients with 
      double-seronegative myasthenia at a tertiary level center. RESULTS: We did not 
      find any significant difference in terms of clinical characteristics, treatment 
      response to immunosuppressants, long-term prognosis, and quality of life. 
      CONCLUSION: Seropositivity for antibodies should not be used in isolation to 
      guide the management or predict the prognosis. Undue negative prognostication may 
      affect the morale of patient. Clinical features and response to therapy in 
      addition to antibody status must be considered before planning therapy.
CI  - Copyright: (c) 2006-2019 Annals of Indian Academy of Neurology.
FAU - Samal, Priyanka
AU  - Samal P
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Goyal, Vinay
AU  - Goyal V
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Singh, Mamta B
AU  - Singh MB
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Padma Srivastava, M V
AU  - Padma Srivastava MV
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC7001455
OTO - NOTNLM
OT  - MuSK
OT  - myasthenia
OT  - prognosis
OT  - quality of life
OT  - rituximab
COIS- There are no conflicts of interest.
EDAT- 2020/02/15 06:00
MHDA- 2020/02/15 06:01
PMCR- 2020/01/01
CRDT- 2020/02/15 06:00
PHST- 2020/02/15 06:00 [entrez]
PHST- 2020/02/15 06:00 [pubmed]
PHST- 2020/02/15 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - AIAN-23-32 [pii]
AID - 10.4103/aian.AIAN_302_19 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2020 Jan-Feb;23(1):32-37. doi: 10.4103/aian.AIAN_302_19.