PMID- 32055440
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2214-2509 (Print)
IS  - 2214-2509 (Electronic)
IS  - 2214-2509 (Linking)
VI  - 19
DP  - 2020
TI  - Immune reconstitution inflammatory syndrome following Cryptococcal neoformans 
      infection in an immunocompetent host: A case report and review of the literature.
PG  - e00699
LID - 10.1016/j.idcr.2020.e00699 [doi]
LID - e00699
AB  - We present a case of Cryptococcus neoformans in an immunocompetent middle-aged 
      woman with a disseminated manifestation of pulmonary cryptoccoma and cryptococcal 
      meningitis resulting in bilateral blindness. The presentation was complicated by 
      delayed diagnosis resulting in optic neuritis and an infected percutaneous lumbar 
      drainage with methicillin resistant staphylococcus aureus (MRSA) and a 
      paradoxical reaction of suspected immune reconstitution inflammatory syndrome 
      (IRIS). We discuss the pathogen, the clinical manifestations and diagnostic 
      approach (through laboratory and radiology findings), differential diagnosis, 
      treatment, and proposed pathogenesis of IRIS and C. neoformans in an 
      immunocompetent patient.
CI  - (c) 2020 The Authors.
FAU - Kathiresu, Raguharan
AU  - Kathiresu R
AD  - Department of Internal Medicine, The Townsville Hospital, Townsville, Queensland, 
      Australia.
FAU - Zinat, Syeda Nabila
AU  - Zinat SN
AD  - Department of Internal Medicine, The Townsville Hospital, Townsville, Queensland, 
      Australia.
FAU - Fernando, Malindu
AU  - Fernando M
AD  - Department of Internal Medicine, The Townsville Hospital, Townsville, Queensland, 
      Australia.
AD  - College of Medicine and Dentistry, James Cook University, Townsville, Queensland, 
      Australia.
LA  - eng
PT  - Case Reports
DEP - 20200109
PL  - Netherlands
TA  - IDCases
JT  - IDCases
JID - 101634540
PMC - PMC7005434
OTO - NOTNLM
OT  - Atypical presentations
OT  - C. neoformans
OT  - Cryptococcus
COIS- None of the authors have any conflicts of interest to disclose with regards to 
      this paper.
EDAT- 2020/02/15 06:00
MHDA- 2020/02/15 06:01
PMCR- 2020/01/09
CRDT- 2020/02/15 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/12/30 00:00 [revised]
PHST- 2020/01/01 00:00 [accepted]
PHST- 2020/02/15 06:00 [entrez]
PHST- 2020/02/15 06:00 [pubmed]
PHST- 2020/02/15 06:01 [medline]
PHST- 2020/01/09 00:00 [pmc-release]
AID - S2214-2509(20)30007-X [pii]
AID - e00699 [pii]
AID - 10.1016/j.idcr.2020.e00699 [doi]
PST - epublish
SO  - IDCases. 2020 Jan 9;19:e00699. doi: 10.1016/j.idcr.2020.e00699. eCollection 2020.