PMID- 32059364
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20231113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 4
DP  - 2020 Feb 12
TI  - Differential Expression of Circulating Inflammatory Proteins Following 
      Sport-Related Traumatic Brain Injury.
LID - 10.3390/ijms21041216 [doi]
LID - 1216
AB  - Sport-related traumatic brain injury (TBI) elicits a multifaceted inflammatory 
      response leading to brain injury and morbidity. This response could be a 
      predictive tool for the progression of TBI and to stratify the injury of which 
      mild TBI is most prevalent. Therefore, we examined the differential expression of 
      serum inflammatory markers overtime and identified novel markers in repetitively 
      concussed athletes. Neuropsychological assessment by Wechsler Adult Intelligence 
      Scale (WAIS) and Immediate Post Concussion Assessment and Cognitive Test (ImPACT) 
      was performed on rugby players and serum was taken from healthy, concussed and 
      repetitively concussed athletes. Serum was also obtained <1 week and >1 week 
      after trauma and analyzed for 92 inflammatory protein markers. Fibroblast growth 
      factor 21 (FGF21) and interleukin-7 (IL-7) differentiated repetitively concussed 
      athletes. Macrophage chemotactic protein-1 (MCP-1), tumor necrosis factor 
      superfamily member 14 (TNFSF14) were significantly reduced >1 week and chemokine 
      (C-X3-C motif) ligand 1 (CX3CL1) upregulated <1 week after injury. FGF21 and 
      MCP-1 negatively correlated with symptoms and their severity. We have identified 
      dynamic changes in the inflammatory response overtime and in different classes of 
      concussion correlating with disease progression. This data supports the use of 
      inflammatory biomarkers as predictors of symptom development due to secondary 
      complications of sport-related mTBI.
FAU - Begum, Ghazala
AU  - Begum G
AD  - Marker Diagnostics Ltd., The BioHub, Edgbaston, Birmingham B15 2SQ, UK.
FAU - Reddy, Rahul
AU  - Reddy R
AD  - University of Illinois, Chicago, IL 60607, USA.
FAU - Yakoub, Kamal M
AU  - Yakoub KM
AD  - Neuroscience & Ophthalmology Research Group, Institute of Inflammation & Ageing, 
      College of Medical and Dental Sciences, University of Birmingham, Edgbaston, 
      Birmingham B15 2TT, UK.
AD  - National Institute for Health Research Surgical Reconstruction and Microbiology 
      Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
FAU - Belli, Antonio
AU  - Belli A
AD  - Neuroscience & Ophthalmology Research Group, Institute of Inflammation & Ageing, 
      College of Medical and Dental Sciences, University of Birmingham, Edgbaston, 
      Birmingham B15 2TT, UK.
AD  - National Institute for Health Research Surgical Reconstruction and Microbiology 
      Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
FAU - Davies, David J
AU  - Davies DJ
AD  - Neuroscience & Ophthalmology Research Group, Institute of Inflammation & Ageing, 
      College of Medical and Dental Sciences, University of Birmingham, Edgbaston, 
      Birmingham B15 2TT, UK.
AD  - National Institute for Health Research Surgical Reconstruction and Microbiology 
      Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
FAU - Di Pietro, Valentina
AU  - Di Pietro V
AD  - Neuroscience & Ophthalmology Research Group, Institute of Inflammation & Ageing, 
      College of Medical and Dental Sciences, University of Birmingham, Edgbaston, 
      Birmingham B15 2TT, UK.
AD  - National Institute for Health Research Surgical Reconstruction and Microbiology 
      Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
LA  - eng
GR  - SRMRC/National Institute for Health Research/
PT  - Journal Article
DEP - 20200212
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CX3CL1 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (FGF21 protein, human)
RN  - 0 (Interleukin-7)
RN  - 0 (TNFSF14 protein, human)
RN  - 0 (Tumor Necrosis Factor Ligand Superfamily Member 14)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Athletes
MH  - Athletic Injuries/complications/*metabolism/physiopathology
MH  - Biomarkers
MH  - Brain Concussion/complications/metabolism/physiopathology
MH  - Brain Injuries, Traumatic/complications/*metabolism/physiopathology
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CX3CL1/metabolism
MH  - Female
MH  - Fibroblast Growth Factors/metabolism
MH  - Humans
MH  - Inflammation
MH  - Interleukin-7/metabolism
MH  - Male
MH  - Neuropsychological Tests
MH  - Tumor Necrosis Factor Ligand Superfamily Member 14/metabolism
MH  - United Kingdom
MH  - Young Adult
PMC - PMC7072845
OTO - NOTNLM
OT  - FGF21
OT  - MCP-1
OT  - concussion
OT  - mild traumatic brain injury
OT  - neuroinflammation
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/16 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/02/01
CRDT- 2020/02/16 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/02/05 00:00 [revised]
PHST- 2020/02/07 00:00 [accepted]
PHST- 2020/02/16 06:00 [entrez]
PHST- 2020/02/16 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - ijms21041216 [pii]
AID - ijms-21-01216 [pii]
AID - 10.3390/ijms21041216 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Feb 12;21(4):1216. doi: 10.3390/ijms21041216.