PMID- 32060741
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 33
IP  - 3
DP  - 2020 Jun
TI  - Recent insights into sodium and potassium handling by the aldosterone-sensitive 
      distal nephron: implications on pathophysiology and drug discovery.
PG  - 447-466
LID - 10.1007/s40620-020-00700-9 [doi]
AB  - As our understanding of the physiology of the aldosterone-sensitive distal 
      nephron (ASDN) advanced in light of novel acquisitions, mainly pertaining the 
      regulation of key ion channels and transporters by with-no-lysine kinases, the 
      pathophysiology of a variety of conditions affecting this segment of the nephron 
      was partly or fully elucidated as well. The pathophysiology of tubulopathies 
      affecting the ASDN or strictly related nephron segments, and disorders causing 
      aldosteronism, pseudoaldosteronism and pseudohypoaldosteronism are here reviewed. 
      The clinical features, with a strong emphasis on pathophysiology, of a variety of 
      disorders are discussed, including: Liddle, Gordon (and calcineurin 
      inhibitor-related hypertension), and Geller syndrome; apparent mineralocorticoid 
      excess; Bartter and Gitelman syndromes; primary aldosteronism, including familial 
      forms; generalized glucocorticoid resistance (Chrousos syndrome). Moreover, the 
      pharmacological translational potential of such novel acquisitions is briefly 
      discussed.
FAU - Rossi, Giovanni Maria
AU  - Rossi GM
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Di Parma, Parma, Italy.
AD  - Dipartimento Di Medicina E Chirurgia, Universita Di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Regolisti, Giuseppe
AU  - Regolisti G
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Di Parma, Parma, Italy.
AD  - Dipartimento Di Medicina E Chirurgia, Universita Di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Peyronel, Francesco
AU  - Peyronel F
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Di Parma, Parma, Italy.
AD  - Dipartimento Di Medicina E Chirurgia, Universita Di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Fiaccadori, Enrico
AU  - Fiaccadori E
AUID- ORCID: 0000-0002-6532-7675
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Di Parma, Parma, Italy. 
      enrico.fiaccadori@unipr.it.
AD  - Dipartimento Di Medicina E Chirurgia, Universita Di Parma, Via Gramsci 14, 43100, 
      Parma, Italy. enrico.fiaccadori@unipr.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200214
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - *Aldosterone
MH  - Drug Discovery
MH  - Humans
MH  - *Hypertension
MH  - Nephrons
MH  - Potassium
MH  - Sodium
OTO - NOTNLM
OT  - ASDN
OT  - Aldosteronism
OT  - ENaC
OT  - Pseudoaldosteronism
OT  - WNK
EDAT- 2020/02/16 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/02/16 06:00
PHST- 2019/08/18 00:00 [received]
PHST- 2020/01/02 00:00 [accepted]
PHST- 2020/02/16 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/02/16 06:00 [entrez]
AID - 10.1007/s40620-020-00700-9 [pii]
AID - 10.1007/s40620-020-00700-9 [doi]
PST - ppublish
SO  - J Nephrol. 2020 Jun;33(3):447-466. doi: 10.1007/s40620-020-00700-9. Epub 2020 Feb 
      14.