PMID- 32060778
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Print)
IS  - 1520-9512 (Linking)
VI  - 24
IP  - 3
DP  - 2020 Sep
TI  - Motor vehicle accidents in CPAP-compliant obstructive sleep apnea patients-a 
      long-term observational study.
PG  - 1089-1095
LID - 10.1007/s11325-020-02023-2 [doi]
AB  - PURPOSE: Obstructive sleep apnea (OSA) has been associated with a 2- to 7-fold 
      risk of motor vehicle accidents (MVAs). Continuous positive airway pressure 
      (CPAP) treatment may reduce MVA risk. We further explored this issue in long-term 
      CPAP users and untreated controls. METHODS: We used both before-after and 
      case-control study designs. The observational cohort consisted of CPAP-treated 
      and untreated patients matched for gender, age, and apnea-hypopnea index. All 
      MVAs reported to the police were identified. RESULTS: A total of 2060 patients 
      (75.8% male, mean age 56.0 +/- 10.5 years) were included. The CPAP-treated patients 
      (N = 1030) were screened for MVAs for a median of 9.0 years before and after 
      treatment. The median CPAP usage was 6.4 h/day. The control patients (N = 1030) 
      were screened for MVAs for a median of 6.5 years after discontinuation of CPAP. 
      No significant differences were observed between the incidences of MVAs per 1000 
      person years before treatment (3.2), after treatment (3.9), or in controls (2.6). 
      Compared with controls, patients who had MVA after treatment had a higher body 
      mass index (BMI), but did not differ in terms of other baseline characteristics, 
      sleep study data, or accident conditions. In the majority of these patients, 
      daytime sleepiness was reduced, whereas BMI tended to increase during treatment. 
      CONCLUSIONS: The MVA incidence did not change after CPAP treatment. Among the 
      patients who had MVA, BMI was the only baseline characteristic that differed 
      between the groups and tended to further increase after CPAP treatment. 
      Differences in sleep study data or accident conditions were not observed.
FAU - Myllyla, Minna
AU  - Myllyla M
AUID- ORCID: 0000-0002-0590-7870
AD  - Department of Pulmonary Diseases, Division of Medicine, Turku University Hospital 
      and University of Turku, Hameentie 11, FI-20520, Turku, Finland. msmyll@utu.fi.
FAU - Anttalainen, Ulla
AU  - Anttalainen U
AD  - Department of Pulmonary Diseases, Division of Medicine, Turku University Hospital 
      and University of Turku, Hameentie 11, FI-20520, Turku, Finland.
AD  - Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, 
      University of Turku, Turku, Finland.
FAU - Saaresranta, Tarja
AU  - Saaresranta T
AD  - Department of Pulmonary Diseases, Division of Medicine, Turku University Hospital 
      and University of Turku, Hameentie 11, FI-20520, Turku, Finland.
AD  - Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, 
      University of Turku, Turku, Finland.
FAU - Laitinen, Tarja
AU  - Laitinen T
AD  - Department of Pulmonary Diseases, Division of Medicine, Turku University Hospital 
      and University of Turku, Hameentie 11, FI-20520, Turku, Finland.
AD  - Hospital Administration, Tampere University Hospital, Tampere, Finland.
LA  - eng
GR  - -/Clinical Research Fund of the Turku University Hospital/
GR  - -/Finnish Anti-Tuberculosis Foundation/
GR  - -/Research Foundation of the Pulmonary Diseases/
GR  - -/Tampere Tuberculosis Foundation/
GR  - -/Emil Aaltonen Foundation/
GR  - -/Turku University Foundation/
GR  - -/Valto Takala Foundation managed by the University Society of Turku/
PT  - Journal Article
PT  - Observational Study
DEP - 20200214
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
SB  - IM
MH  - Accidents, Traffic/*statistics & numerical data
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Continuous Positive Airway Pressure/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Sleep Apnea, Obstructive/*epidemiology/*therapy
PMC - PMC7426312
OTO - NOTNLM
OT  - Continuous positive airway pressure
OT  - Motor vehicle accident
OT  - Obstructive sleep apnea
OT  - Real-world study
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/02/16 06:00
MHDA- 2021/10/26 06:00
PMCR- 2020/02/14
CRDT- 2020/02/16 06:00
PHST- 2019/11/06 00:00 [received]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2020/01/18 00:00 [revised]
PHST- 2020/02/16 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/02/16 06:00 [entrez]
PHST- 2020/02/14 00:00 [pmc-release]
AID - 10.1007/s11325-020-02023-2 [pii]
AID - 2023 [pii]
AID - 10.1007/s11325-020-02023-2 [doi]
PST - ppublish
SO  - Sleep Breath. 2020 Sep;24(3):1089-1095. doi: 10.1007/s11325-020-02023-2. Epub 
      2020 Feb 14.