PMID- 32061662
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210402
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 191
DP  - 2020 Apr
TI  - Synthetic psychoactive cathinones: hypothermia and reduced lethality compared to 
      methamphetamine and methylenedioxymethamphetamine.
PG  - 172871
LID - S0091-3057(19)30419-8 [pii]
LID - 10.1016/j.pbb.2020.172871 [doi]
AB  - RATIONALE: Synthetic psychoactive cathinones (SPCs) are drugs with 
      psychostimulant and entactogenic properties like methamphetamine (MA) and 
      3,4-methylenedioxymethamphetamine (MDMA). Despite clinical reports of human 
      overdose, it remains to be determined if SPCs have greater propensity for adverse 
      effects than MA or MDMA. OBJECTIVES: To determine whether the SPCs cathinone 
      (CAT), methcathinone (MCAT), mephedrone (MMC), and methylenedioxypyrovalerone 
      (MDPV) have lower LD50 values than MA or MDMA. METHODS: Male and female C57Bl/6J 
      mice received single injections of one of 6 doses of a test drug (0-160 mg/kg 
      IP). Temperature and behavioral observations were taken every 20 min for 2 h 
      followed by euthanasia of surviving mice. Organs were weighed and evaluated for 
      histopathological changes. RESULTS: LD50 values for MA and MDMA, 84.5 and 
      100.9 mg/kg respectively, were similar to previous observations. The LD50 for MMC 
      was 118.8 mg/kg, but limited lethality was observed for other SPCs (CAT, MCAT, 
      MDPV), so LD50 values could not be calculated. For all drugs, death was 
      associated with seizure, when it was observed. Rather than hyperthermia, 
      dose-dependent hypothermia was observed for MMC, MDPV, CAT, and MCAT. Contrary to 
      initial expectations, none of the SPCs studied here had LD50 values lower than MA 
      or MDMA. CONCLUSIONS: These data indicate that, under the conditions studied 
      here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair 
      thermoregulation; (3) effects of SPCs on temperature appear to be independent of 
      effects on lethality.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Muskiewicz, Dawn E
AU  - Muskiewicz DE
AD  - Department of Pharmacology and Experimental Therapeutics, University of Toledo 
      College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, 
      OH, United States of America.
FAU - Resendiz-Gutierrez, Federico
AU  - Resendiz-Gutierrez F
AD  - Department of Pharmacology and Experimental Therapeutics, University of Toledo 
      College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, 
      OH, United States of America.
FAU - Issa, Omar
AU  - Issa O
AD  - Department of Pharmacology and Experimental Therapeutics, University of Toledo 
      College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, 
      OH, United States of America.
FAU - Hall, F Scott
AU  - Hall FS
AD  - Department of Pharmacology and Experimental Therapeutics, University of Toledo 
      College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, 
      OH, United States of America. Electronic address: frank.hall@utoledo.edu.
LA  - eng
GR  - R03 DA045350/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200212
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Alkaloids)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Synthetic Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 540EI4406J (cathinone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Alkaloids/administration & dosage/adverse effects/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Body Temperature Regulation/drug effects
MH  - Central Nervous System Stimulants/administration & dosage/adverse 
      effects/*pharmacology
MH  - Female
MH  - Hypothermia/*chemically induced
MH  - Lethal Dose 50
MH  - Locomotion/drug effects
MH  - Male
MH  - Methamphetamine/administration & dosage/adverse effects/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/adverse 
      effects/*pharmacology
MH  - Psychotropic Drugs/administration & dosage/adverse effects/*pharmacology
MH  - Seizures/*chemically induced/*mortality
MH  - Synthetic Drugs/administration & dosage/adverse effects/*pharmacology
PMC - PMC7195606
MID - NIHMS1567424
OTO - NOTNLM
OT  - Cathinone
OT  - Lethality
OT  - Mephedrone
OT  - Methamphetamine
OT  - Methcathinone
OT  - Methylenedioxymethamphetamine
OT  - Methylenedioxypyrovalerone
OT  - Synthetic psychoactive cathinones
OT  - Temperature regulation
EDAT- 2020/02/18 06:00
MHDA- 2021/01/08 06:00
PMCR- 2021/04/01
CRDT- 2020/02/17 06:00
PHST- 2019/08/30 00:00 [received]
PHST- 2019/12/16 00:00 [revised]
PHST- 2020/02/11 00:00 [accepted]
PHST- 2020/02/18 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/02/17 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S0091-3057(19)30419-8 [pii]
AID - 10.1016/j.pbb.2020.172871 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2020 Apr;191:172871. doi: 10.1016/j.pbb.2020.172871. 
      Epub 2020 Feb 12.