PMID- 32062072
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 81
DP  - 2020 Apr
TI  - Activation of activating Fc gamma receptors down-regulates the levels of 
      interferon beta, interferon gamma and interferon lambda1 in porcine alveolar macrophages 
      during PRRSV infection.
PG  - 106268
LID - S1567-5769(19)32507-X [pii]
LID - 10.1016/j.intimp.2020.106268 [doi]
AB  - Porcine activating Fc gamma receptors (FcgammaRI and FcgammaRIII) have been cloned and 
      characterized for many years. However, their roles in interferon (IFN) antiviral 
      immune response to porcine reproductive and respiratory syndrome virus (PRRSV) 
      infection have not yet been investigated extensively. In this study, PRRSV 
      infection assay showed that PRRSV increased significantly the transcription of 
      IFN-beta, IFN-gamma and IFN-lambda1 in porcine alveolar macrophages (PAMs) in early infection 
      and decreased significantly the transcription of IFN-beta, IFN-gamma and IFN-lambda1 in PAMs 
      in late infection. Activation assay showed that specific activation of FcgammaRI or 
      FcgammaRIII in PAMs decreased significantly the transcription of IFN-beta, IFN-gamma and 
      IFN-lambda1 and increased significantly the transcription of transforming growth 
      factor beta1 (TGF-beta1). PRRSV infection assay mediated by FcgammaRI and FcgammaRIII showed 
      that specific activation of FcgammaRI or FcgammaRIII in PAMs during PRRSV infection 
      decreased significantly the transcription of IFN-beta, IFN-gamma and IFN-lambda1, but 
      increased significantly the transcription of TGF-beta1 and enhanced significantly 
      viral replication. In conclusion, our studies suggested that activating FcgammaR 
      signaling inhibited the transcriptional levels of IFN-beta, IFN-gamma and IFN-lambda1 in PAMs 
      in response to PRRSV infection.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhang, Liujun
AU  - Zhang L
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Li, Wen
AU  - Li W
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Sun, Yangyang
AU  - Sun Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Li, Xiangtong
AU  - Li X
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Kong, Linghao
AU  - Kong L
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Xu, Pengli
AU  - Xu P
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China.
FAU - Xia, Pingan
AU  - Xia P
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China. Electronic address: xpa88@163.com.
FAU - Yue, Junming
AU  - Yue J
AD  - Department of Pathology and Laboratory Medicine, University of Tennessee Health 
      Science Center, Memphis, TN 38163, USA; Center for Cancer Research, University of 
      Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: 
      jyue@uthsc.edu.
LA  - eng
PT  - Journal Article
DEP - 20200213
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Receptors, IgG)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 77238-31-4 (Interferon-beta)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Down-Regulation
MH  - Immune Evasion
MH  - Interferon-beta/*metabolism
MH  - Interferon-gamma/*metabolism
MH  - Interferons/*metabolism
MH  - Macrophages, Alveolar/*immunology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Receptors, IgG/*metabolism
MH  - Signal Transduction
MH  - Swine
MH  - Transforming Growth Factor beta1/metabolism
MH  - Virus Replication
OTO - NOTNLM
OT  - FcgammaRI
OT  - FcgammaRIII
OT  - IFN
OT  - PAMs
OT  - PRRSV
COIS- Declaration of Competing Interest The authors declare that they have no any 
      competing interests.
EDAT- 2020/02/18 06:00
MHDA- 2021/01/08 06:00
CRDT- 2020/02/17 06:00
PHST- 2019/11/04 00:00 [received]
PHST- 2020/01/28 00:00 [revised]
PHST- 2020/01/28 00:00 [accepted]
PHST- 2020/02/18 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/02/17 06:00 [entrez]
AID - S1567-5769(19)32507-X [pii]
AID - 10.1016/j.intimp.2020.106268 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2020 Apr;81:106268. doi: 10.1016/j.intimp.2020.106268. Epub 
      2020 Feb 13.