PMID- 32062387
OWN - NLM
STAT- MEDLINE
DCOM- 20200311
LR  - 20200311
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 204
DP  - 2020 Mar
TI  - In-vitro photothermal therapy using plant extract polyphenols functionalized 
      graphene sheets for treatment of lung cancer.
PG  - 111587
LID - S1011-1344(19)30247-7 [pii]
LID - 10.1016/j.jphotobiol.2019.111587 [doi]
AB  - Although the photothermal therapy (PTT) has achieved tremendous progress in the 
      recent times, still it has to improve an extensive way to achieve the efficient 
      targeted photothermal removal of the tumor cells. Owing to this requirement, we 
      demonstrated a novel class of reduced graphene oxide based photothermal 
      therapeutic agent for the ablation of lung cancer cells (A549). A single step bio 
      facile fabrication of graphene nanosheets using Memecylon edule leaf extract 
      intermediated reduction of Graphene Oxide (GO). This process does not include the 
      utilization of any toxic or harmful reducing agents. The relative results of 
      different characterizations of graphene oxide and Memecylon edule leaf extract 
      RGO delivers a potential representation by excluding the groups containing oxygen 
      from GO and consecutive stabilization of the developed RGO. The reduced GO 
      functionalization with the oxidized polyphenols results in their stability by 
      avoiding the aggregation. The poly phenol anchored Reduced Graphene Oxide (RGO) 
      exhibited exceptional near-infrared (NIR) irradiation of the lung cancer cells 
      directed in vitro to deliver cytotoxicity. In an area of restricted success in 
      the treatment of cancer, the results of our translation can provide a path for 
      designing targeted PTT agents and also responds to stimulus environment for the 
      safe ablation of the devastating disease.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Wang, Chunmei
AU  - Wang C
AD  - Department of Thoracic and Cardiovascular Surgery, Huaihe Hospital of Henan 
      University, China.
FAU - Wang, Xiangyun
AU  - Wang X
AD  - Department of Respiratory and Critical Care Medicine, Changzheng Hospital, Second 
      Military Medical University, China. Electronic address: 
      wangxiangyun2005@smmu.edu.cn.
FAU - Chen, Yang
AU  - Chen Y
AD  - Department of Respiratory and Critical Care Medicine, Changzheng Hospital, Second 
      Military Medical University, China.
FAU - Fang, Zheng
AU  - Fang Z
AD  - Department of Respiratory and Critical Care Medicine, Changzheng Hospital, Second 
      Military Medical University, China. Electronic address: zhengfang70@outlook.com.
LA  - eng
PT  - Journal Article
DEP - 20190809
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects/radiation effects
MH  - Dogs
MH  - Graphite/*chemistry
MH  - Green Chemistry Technology
MH  - Humans
MH  - *Infrared Rays
MH  - Lung Neoplasms/pathology/therapy
MH  - Madin Darby Canine Kidney Cells
MH  - Magnoliopsida/chemistry/metabolism
MH  - Nanostructures/*chemistry/therapeutic use/toxicity
MH  - Phototherapy/methods
MH  - Plant Extracts/chemistry
MH  - Plant Leaves/chemistry/metabolism
MH  - Polyphenols/*chemistry
OTO - NOTNLM
OT  - A549
OT  - PTT
OT  - RGO
EDAT- 2020/02/18 06:00
MHDA- 2020/03/12 06:00
CRDT- 2020/02/17 06:00
PHST- 2019/02/22 00:00 [received]
PHST- 2019/05/04 00:00 [revised]
PHST- 2019/08/08 00:00 [accepted]
PHST- 2020/02/18 06:00 [pubmed]
PHST- 2020/03/12 06:00 [medline]
PHST- 2020/02/17 06:00 [entrez]
AID - S1011-1344(19)30247-7 [pii]
AID - 10.1016/j.jphotobiol.2019.111587 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2020 Mar;204:111587. doi: 
      10.1016/j.jphotobiol.2019.111587. Epub 2019 Aug 9.