PMID- 32062441 OWN - NLM STAT- MEDLINE DCOM- 20200914 LR - 20210402 IS - 1873-6750 (Electronic) IS - 0160-4120 (Print) IS - 0160-4120 (Linking) VI - 137 DP - 2020 Apr TI - Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident. PG - 105526 LID - S0160-4120(19)32546-2 [pii] LID - 10.1016/j.envint.2020.105526 [doi] AB - Widespread polybrominated biphenyls (PBBs) contamination occurred in Michigan from 1973 to 1974, when PBBs were accidentally substituted for a nutritional supplement in livestock feed. People who lived in the state were exposed to PBBs via several routes including ingestion, inhalation and skin absorption. PBBs sequestered in lipid-rich matrices such as adipose tissue, are slowly eliminated after entering the human body, and can also be transferred from a mother to her offspring through the placenta and breastfeeding. Due to the long biological half-lives of PBBs, as well as concerns from the exposed community, biomonitoring measurements were conducted from 2012 to 2015. Because of their similar structures, serum PBBs, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were all measured 40 years after the PBB contamination incident (N = 862). The serum PBB-153 levels among the original highly-exposed groups (i.e., chemical workers, the family of chemical workers, and individuals who lived on or received food from the contaminated farms) remains significantly higher than other Michigan residents. Several predictors such as sampling age, sex, and smoking status were significantly associated with the serum levels of some persistent organic pollutants (POPs). Higher average values and also wider ranges of serum POP levels were found in this study compared to the National Health and Nutrition Examination Survey (NHANES), with the most substantial difference in serum PBB-153. This was true for all groups of Michigan residents including those who were not part of the above-described highly-exposed groups. Moreover, the people born after the contamination incident began also have higher serum PBB-153 levels when compared with more recent NHANES data (2010-2014), which suggests potential intergenerational exposure and/or continued environmental exposure following the contamination period. CI - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Chang, Che-Jung AU - Chang CJ AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. Electronic address: che-jung.chang@emory.edu. FAU - Terrell, Metrecia L AU - Terrell ML AD - Department of Epidemiology, Rollins School of Public Health, Emory University, USA. FAU - Marcus, Michele AU - Marcus M AD - Department of Epidemiology, Rollins School of Public Health, Emory University, USA. FAU - Marder, M Elizabeth AU - Marder ME AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. FAU - Panuwet, Parinya AU - Panuwet P AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. FAU - Ryan, P Barry AU - Ryan PB AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. FAU - Pearson, Melanie AU - Pearson M AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. FAU - Barton, Hillary AU - Barton H AD - Department of Epidemiology, Rollins School of Public Health, Emory University, USA. FAU - Barr, Dana Boyd AU - Barr DB AD - Department of Environmental Health, Rollins School of Public Health, Emory University, USA. LA - eng GR - T32 ES012870/ES/NIEHS NIH HHS/United States GR - R01 ES012014/ES/NIEHS NIH HHS/United States GR - P30 ES019776/ES/NIEHS NIH HHS/United States GR - R24 ES028528/ES/NIEHS NIH HHS/United States GR - R21 ES023927/ES/NIEHS NIH HHS/United States GR - R01 ES025775/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20200218 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Polybrominated Biphenyls) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Child MH - Child, Preschool MH - Environmental Exposure MH - *Environmental Pollutants/blood MH - Female MH - *Halogenated Diphenyl Ethers/blood MH - Humans MH - Intergenerational Relations MH - Male MH - Michigan MH - Middle Aged MH - Nutrition Surveys MH - *Polybrominated Biphenyls/blood MH - *Polychlorinated Biphenyls/blood MH - Pregnancy MH - Registries MH - Young Adult PMC - PMC7201813 MID - NIHMS1568823 OTO - NOTNLM OT - Biomonitoring OT - Michigan PBB Registry OT - Persistent organic pollutants (POPs) OT - Polybrominated biphenyls (PBBs) OT - Polybrominated diphenyl ethers (PBDEs) OT - Polychlorinated biphenyls (PCBs) COIS- Declaration of interests check mark The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/02/18 06:00 MHDA- 2020/09/15 06:00 PMCR- 2021/04/01 CRDT- 2020/02/17 06:00 PHST- 2019/07/24 00:00 [received] PHST- 2019/12/15 00:00 [revised] PHST- 2020/01/24 00:00 [accepted] PHST- 2020/02/18 06:00 [pubmed] PHST- 2020/09/15 06:00 [medline] PHST- 2020/02/17 06:00 [entrez] PHST- 2021/04/01 00:00 [pmc-release] AID - S0160-4120(19)32546-2 [pii] AID - 10.1016/j.envint.2020.105526 [doi] PST - ppublish SO - Environ Int. 2020 Apr;137:105526. doi: 10.1016/j.envint.2020.105526. Epub 2020 Feb 18.