PMID- 32063406
OWN - NLM
STAT- MEDLINE
DCOM- 20210816
LR  - 20210816
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 39
IP  - 10
DP  - 2020 Oct
TI  - Prospective association of physical activity and inflammatory biomarkers in older 
      adults from the PREDIMED-Plus study with overweight or obesity and metabolic 
      syndrome.
PG  - 3092-3098
LID - S0261-5614(20)30038-8 [pii]
LID - 10.1016/j.clnu.2020.01.015 [doi]
AB  - BACKGROUND: There is limited prospective evidence on the association between 
      physical activity (PA) and inflammation in older adults. Our aim was to assess 
      the associations between changes in PA and changes in the inflammatory profile in 
      older individuals who are overweight or obese. METHODS: This prospective study 
      included 489 men and women, aged 55-75 years, from the PREDIMED-Plus trial. 
      Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), 
      monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity 
      C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell 
      expressed and secreted chemokine (RANTES) were obtained from fasting blood 
      samples and a composite inflammatory score based on these biomarkers was 
      calculated. Physical activity was measured by a validated questionnaire. All 
      measures were taken at baseline and one-year follow-up. RESULTS: Multiple linear 
      regression models showed an association between an increase in total PA and a 
      decrease in the inflammatory score (p = 0.012), which was particularly driven by 
      a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased 
      with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006). 
      CONCLUSIONS: Increases in total PA, moderate and moderate-to-vigorous PA were 
      associated with a decrease in the inflammatory profile of obese or overweight 
      older individuals. This finding is relevant for PA recommendations and public 
      health strategies. CLINICAL TRIAL REGISTRY: Clinical trial identifier: 
      International Standard Randomized Controlled Trial 89898870.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Fuentes, Gabriela Cardenas
AU  - Fuentes GC
AD  - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar 
      Medical Research Institute (IMIM), Barcelona, Spain; Biomedicine Program, 
      Department of Experimental and Health Sciences, Pompeu Fabra University, 
      Barcelona, Spain.
FAU - Castaner, Olga
AU  - Castaner O
AD  - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar 
      Medical Research Institute (IMIM), Barcelona, Spain; CIBER de Fisiopatologia de 
      la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, 
      Spain.
FAU - Warnberg, Julia
AU  - Warnberg J
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Nursing, School of Health 
      Sciences. University of Malaga, Malaga, Spain.
FAU - Subirana, Isaac
AU  - Subirana I
AD  - Cardiovascular Epidemiology and Genetics Research Group, IMIM (Hospital del Mar 
      Medical Research Institute), Barcelona, Spain; CIBER Epidemiologia y Salud 
      Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
FAU - Buil-Cosiales, Pilar
AU  - Buil-Cosiales P
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public 
      Health, University of Navarra-Navarra Institute for Health Research, Pamplona, 
      Spain; Primary Health Care Services-Osasunbidea, Pamplona, Navarra, Spain.
FAU - Salas-Salvado, Jordi
AU  - Salas-Salvado J
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Human Nutrition Unit, University Hospital of 
      Sant Joan de Reus Department of Biochemistry and Biotechnology, Pere Virgili 
      Institute for Health Research, Rovira i Virgili University, Reus, Spain.
FAU - Corella, Dolores
AU  - Corella D
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of 
      Valencia, Valencia, Spain.
FAU - Serra-Majem, Lluis
AU  - Serra-Majem L
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Research Institute of Biomedical and Health 
      Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 
      Spain.
FAU - Romaguera, Dora
AU  - Romaguera D
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Instituto de Investigacion Sanitaria Illes 
      Balears (IdISBa), University Hospital of Son Espases, Palma de Mallorca, Spain.
FAU - Estruch, Ramon
AU  - Estruch R
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Internal Medicine, Hospital 
      Clinic, IDIBAPS August Pi i Sunyer Biomedical Research Institute, University of 
      Barcelona, Barcelona, Spain.
FAU - Martinez, J Alfredo
AU  - Martinez JA
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Nutrition, Food Sciences and 
      Physiology, Center for Nutrition Research, University of Navarra, Pamplona, 
      Spain, Madrid Institute for Advanced Studies (IMDEA) Food Institute, Madrid, 
      Spain.
FAU - Pinto, Xavier
AU  - Pinto X
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Lipid Unit, Department of Internal Medicine, 
      Bellvitge Biomedical Research Institute (IDIBELL)-Hospital Universitari de 
      Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Vazquez, Clotilde
AU  - Vazquez C
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Endocrinology and Nutrition, 
      University Hospital Fundacion Jimenez Diaz, Madrid, Spain.
FAU - Vidal, Josep
AU  - Vidal J
AD  - Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain; 
      CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de 
      Salud Carlos III, Madrid, Spain.
FAU - Tur, Josep A
AU  - Tur JA
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Research Group on Community Nutrition and 
      Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain.
FAU - Aros, Fernando
AU  - Aros F
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; OSI ARABA. University Hospital Araba, Department 
      of Cardiology University of the Basque Country UPV/EHU Vitoria-Gasteiz, Spain.
FAU - Bullo, Monica
AU  - Bullo M
AD  - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain; Department of Biochemistry and Biotechnology, 
      Human Nutrition Unit, Hospital Universitari Sant Joan de Reus, Reus, Spain.
FAU - Fito, Montserrat
AU  - Fito M
AD  - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar 
      Medical Research Institute (IMIM), Barcelona, Spain; CIBER de Fisiopatologia de 
      la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, 
      Spain. Electronic address: MFito@imim.es.
FAU - Schroder, Helmut
AU  - Schroder H
AD  - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar 
      Medical Research Institute (IMIM), Barcelona, Spain; CIBER Epidemiologia y Salud 
      Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Electronic 
      address: hschroeder@imim.es.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200203
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Diet, Healthy
MH  - Diet, Mediterranean
MH  - *Exercise
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Metabolic Syndrome/*blood/diagnosis/epidemiology/therapy
MH  - Middle Aged
MH  - Obesity/*blood/diagnosis/epidemiology/therapy
MH  - Patient Education as Topic
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Spain/epidemiology
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Inflammation
OT  - Inflammatory score
OT  - Light physical activity
OT  - Moderate-to-vigorous physical activity
OT  - Prospective study
COIS- Conflict of interest The authors declare that they have no competing interests.
EDAT- 2020/02/18 06:00
MHDA- 2021/08/17 06:00
CRDT- 2020/02/18 06:00
PHST- 2019/07/08 00:00 [received]
PHST- 2020/01/09 00:00 [revised]
PHST- 2020/01/22 00:00 [accepted]
PHST- 2020/02/18 06:00 [pubmed]
PHST- 2021/08/17 06:00 [medline]
PHST- 2020/02/18 06:00 [entrez]
AID - S0261-5614(20)30038-8 [pii]
AID - 10.1016/j.clnu.2020.01.015 [doi]
PST - ppublish
SO  - Clin Nutr. 2020 Oct;39(10):3092-3098. doi: 10.1016/j.clnu.2020.01.015. Epub 2020 
      Feb 3.