PMID- 32063564
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 267
DP  - 2020 Apr 15
TI  - L-Carnosine combination therapy for major depressive disorder: A randomized, 
      double-blind, placebo-controlled trial.
PG  - 131-136
LID - S0165-0327(19)30993-0 [pii]
LID - 10.1016/j.jad.2020.02.020 [doi]
AB  - BACKGROUND: Evidence for antidepressant effects of L-Carnosine was shown in some 
      experimental studies. In this study we tried to evaluate the efficacy and 
      tolerability of L-Carnosine combination therapy in treatment of patients with 
      major depressive disorder (MDD). METHODS: Fifty-eight patients with MDD (DSM-V) 
      and Hamilton Depression Rating Scale (HAM-D) score >/= 19 were randomized to 
      receive either 400 mg twice daily L-Carnosine or placebo in addition to 
      citalopram (maximum dosage of 40 mg/day) for six weeks in a randomized 
      double-blind, and placebo-controlled study. Patients were assessed using the 
      HAM-D scale at baseline and weeks 2, 4, and 6. RESULTS: Fifty-two patients 
      completed the trial. General linear model repeated measure showed significant 
      difference for time x treatment on HAM-D score [F = 3.17, df = 2.39, 
      p-value = 0.03]. Significantly greater improvement was detected in HAM-D score of 
      the L-Carnosine group compared with the placebo group from baseline to weeks 2, 4 
      and 6 [Ps = 0.013, 0.028 and 0.023; respectively]. Patients in the L-Carnosine 
      group experienced significantly greater response and remission rate than the 
      placebo group [Ps = 0.023 and 0.012; respectively]. There was no significant 
      difference between the two groups in baseline parameters and frequency of side 
      effects. LIMITATIONS: Short follow-up period and small population size were two 
      important limitations of this study. CONCLUSIONS: L-Carnosine combination therapy 
      with citalopram can effectively improve symptoms of patients with major 
      depressive disorder. Rapid-onset antidepressant effects of L-Carnosine were also 
      shown which need further investigation.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Araminia, Behin
AU  - Araminia B
AD  - Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Shalbafan, Mohammadreza
AU  - Shalbafan M
AD  - Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Mortezaei, Amirhosein
AU  - Mortezaei A
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran.
FAU - Shirazi, Elham
AU  - Shirazi E
AD  - Mental Health Research Center, School of Behavioral Sciences and Mental Health, 
      Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Ghaffari, Salomeh
AU  - Ghaffari S
AD  - School of Persian Medicine, Iran University of Medical Sciences, Research 
      Institute for Islamic and Complementary Medicine, Tehran, Iran.
FAU - Sahebolzamani, Erfan
AU  - Sahebolzamani E
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran.
FAU - Mortazavi, Seyyed Hosein
AU  - Mortazavi SH
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran.
FAU - Shariati, Behnam
AU  - Shariati B
AD  - Mental Health Research Center, School of Behavioral Sciences and Mental Health, 
      Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Ardebili, Mehrdad Eftekhar
AU  - Ardebili ME
AD  - Mental Health Research Center, School of Behavioral Sciences and Mental Health, 
      Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Aqamolaei, Ali
AU  - Aqamolaei A
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran.
FAU - Naderi, Sina
AU  - Naderi S
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran.
FAU - Akhondzadeh, Shahin
AU  - Akhondzadeh S
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, South Kargar Street, Tehran, Iran. Electronic address: 
      s.akhond@neda.net.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200207
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 8HO6PVN24W (Carnosine)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - *Carnosine/therapeutic use
MH  - Citalopram/therapeutic use
MH  - *Depressive Disorder, Major/drug therapy
MH  - Double-Blind Method
MH  - Humans
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Glutamate
OT  - L-Carnosine
OT  - Major depressive disorder (MDD)
OT  - Randomized controlled trial
COIS- Declaration of Competing Interest All authors declare that they have no conflict 
      of interest.
EDAT- 2020/02/18 06:00
MHDA- 2021/02/16 06:00
CRDT- 2020/02/18 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2020/01/15 00:00 [revised]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/02/18 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
PHST- 2020/02/18 06:00 [entrez]
AID - S0165-0327(19)30993-0 [pii]
AID - 10.1016/j.jad.2020.02.020 [doi]
PST - ppublish
SO  - J Affect Disord. 2020 Apr 15;267:131-136. doi: 10.1016/j.jad.2020.02.020. Epub 
      2020 Feb 7.