PMID- 32067095
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 277
IP  - 5
DP  - 2020 May
TI  - Identification of core biomarkers associated with pathogenesis and prognostic 
      outcomes of laryngeal squamous-cell cancer using bioinformatics analysis.
PG  - 1397-1408
LID - 10.1007/s00405-020-05856-5 [doi]
AB  - PURPOSE: Despite advances in the treatment of laryngeal squamous-cell carcinoma 
      (LSCC), the survival rate of LSCC remains poor. Thereby, it is urgent to identify 
      novel diagnostic and prognostic biomarkers for LSCC. The study aimed to identify 
      potential core genes associated with the pathogenesis and prognosis of LSCC. 
      METHODS: Differentially expressed genes between LSCC and normal laryngeal tissue 
      samples were screened by an integrated analysis of data from GEO and TCGA 
      databases. Core genes related to the pathogenesis and prognosis of LSCC were 
      identified by employing protein-protein interaction network and Cox proportional 
      hazards model analyses. RESULTS: Ten hub genes (AURKA, AURKB, CDC45, KIF2C, 
      NDC80, EXO1, TYMS, RAD51AP1, ITGA3, and UBE2T) that might be highly related to 
      the pathogenesis of LSCC were identified. An eight-gene prognostic signature 
      consisted of ZG16B, STATH, RTN4R, MSRA, CBX8, SLC5A1, EFNB1 and CNTFR was 
      constructed with a good performance in predicting overall survivals. CONCLUSION: 
      Our findings might shed some new light on the pathogenesis of LSCC and help 
      identify new therapeutic targets of LSCC.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Otolaryngology, Fujian Medical University Union Hospital, 29# 
      Xinquan Road, Fujian, 350001, Fuzhou, China.
FAU - Liao, Lianming
AU  - Liao L
AD  - Department of Laboratory Medicine, Fujian Medical University Union Hospital, 
      Fujian, 350001, Fuzhou, China.
FAU - Lai, Haichun
AU  - Lai H
AD  - Department of Otolaryngology, Fujian Medical University Union Hospital, 29# 
      Xinquan Road, Fujian, 350001, Fuzhou, China.
FAU - Yi, Xuehan
AU  - Yi X
AD  - Department of Otolaryngology, Fujian Medical University Union Hospital, 29# 
      Xinquan Road, Fujian, 350001, Fuzhou, China.
FAU - Wang, Desheng
AU  - Wang D
AUID- ORCID: 0000-0002-5844-0813
AD  - Department of Otolaryngology, Fujian Medical University Union Hospital, 29# 
      Xinquan Road, Fujian, 350001, Fuzhou, China. wangds@fjmu.edu.cn.
LA  - eng
GR  - 2016J01548/Natural Science Foundation of Fujian Province/
GR  - JS15019/Professor Foundation of Fujian Medical University/
GR  - 2017-CX-23/Medical Innovation Project of Fujian Medical University/
PT  - Journal Article
DEP - 20200217
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CBX8 protein, human)
RN  - 0 (STATH protein, human)
RN  - 0 (Salivary Proteins and Peptides)
RN  - EC 2.3.2.23 (UBE2T protein, human)
RN  - EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes)
RN  - EC 2.3.2.27 (Polycomb Repressive Complex 1)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Computational Biology
MH  - Gene Expression Regulation, Neoplastic
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics
MH  - Polycomb Repressive Complex 1
MH  - Prognosis
MH  - Salivary Proteins and Peptides
MH  - Ubiquitin-Conjugating Enzymes
OTO - NOTNLM
OT  - Bioinformatics analysis
OT  - Biomarkers
OT  - GEO
OT  - Laryngeal squamous-cell carcinoma (LSCC)
OT  - Prognostic gene signature
OT  - TCGA
EDAT- 2020/02/19 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/02/19 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/02/19 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/02/19 06:00 [entrez]
AID - 10.1007/s00405-020-05856-5 [pii]
AID - 10.1007/s00405-020-05856-5 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2020 May;277(5):1397-1408. doi: 
      10.1007/s00405-020-05856-5. Epub 2020 Feb 17.