PMID- 32067207
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230613
IS  - 1873-9601 (Print)
IS  - 1873-961X (Electronic)
IS  - 1873-9601 (Linking)
VI  - 14
IP  - 2
DP  - 2020 Jun
TI  - Long non-coding RNA TP73-AS1 promotes TFAP2B-mediated proliferation, metastasis 
      and invasion in retinoblastoma via decoying of miRNA-874-3p.
PG  - 193-205
LID - 10.1007/s12079-020-00550-x [doi]
AB  - Retinoblastoma (RB) is one of the most common ophthalmic tumors, and most of the 
      patients have been identified as advanced at the time of diagnosis, which is 
      directly related to high mortality. Recent studies showed that long noncoding RNA 
      (lncRNA) and miRNAs play key roles in the development、progression、or treatment of 
      cancer, such as RB. However, the role of lncRNA -TP73-AS1 in RB remains unclear. 
      In this study, we performed functional and mechanistic investigation of 
      miRNA-874-3p-TP73-AS1 interaction in RB. The experiments results revealed that 
      miRNA-874-3p had anti-oncogenic functions in RB. Moreover, the bioinformatics 
      analysis shown that TP73-AS1 could bind to miRNA-874-3p. TP73-AS1 was inversely 
      correlated with miRNA-874-3p expression. Furthermore, studies confirmed that 
      TP73-AS1 negatively regulated miRNA-874-3p expression via functioning as a ceRNA. 
      In a word, our results suggest that the TP73-AS1/ miRNA-874-3p / TFAP2B 
      (transcription factor activating enhancer-binding protein 2B) pathway contributes 
      to the progression of RB, which may provide novel insights into the function of 
      lncRNA-driven retinoblastogenesis. Graphical abstract.
FAU - Wang, Lina
AU  - Wang L
AD  - Tianjin First Central Hospital, Tianjin, China.
AD  - Tianjin Medical University Eye Hospital, Tianjin, China.
FAU - Wang, Chaokui
AU  - Wang C
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab 
      of Ophthalmology, Chongqing Eye Institute, Chongqing, People's Republic of China.
FAU - Wu, Tong
AU  - Wu T
AD  - Tianjin Medical University Eye Hospital, Tianjin, China.
FAU - Sun, Fengyuan
AU  - Sun F
AUID- ORCID: 0000-0002-9274-5223
AD  - Tianjin Medical University Eye Hospital, Tianjin, China. ydyk2016@126.com.
LA  - eng
GR  - 81800813/National Natural Science Foundation Project/
PT  - Journal Article
PT  - Retracted Publication
DEP - 20200218
PL  - Netherlands
TA  - J Cell Commun Signal
JT  - Journal of cell communication and signaling
JID - 101308338
RIN - J Cell Commun Signal. 2023 Sep;17(3):1121. PMID: 37310655
PMC - PMC7272539
OTO - NOTNLM
OT  - Retinoblastoma(RB)
OT  - Transcription factor activating enhancer-binding protein 2B (TFAP2B)
OT  - WNT/beta-catenin pathway
OT  - lncRNA-TP73-AS1
OT  - miR-874-3p
COIS- There are none.
EDAT- 2020/02/19 06:00
MHDA- 2020/02/19 06:01
PMCR- 2020/06/01
CRDT- 2020/02/19 06:00
PHST- 2019/07/18 00:00 [received]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/02/19 06:00 [pubmed]
PHST- 2020/02/19 06:01 [medline]
PHST- 2020/02/19 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - 10.1007/s12079-020-00550-x [pii]
AID - 550 [pii]
AID - 10.1007/s12079-020-00550-x [doi]
PST - ppublish
SO  - J Cell Commun Signal. 2020 Jun;14(2):193-205. doi: 10.1007/s12079-020-00550-x. 
      Epub 2020 Feb 18.