PMID- 32068453
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 140
IP  - 5
DP  - 2020 May
TI  - Serum miR-632 is a potential marker for the diagnosis and prognosis in laryngeal 
      squamous cell carcinoma.
PG  - 418-421
LID - 10.1080/00016489.2020.1717610 [doi]
AB  - Background: It has been demonstrated that miRNAs play critical roles in the 
      tumorigenesis and progression of various tumors.Objective: The purpose of this 
      research was to determine the serum miR-632 levels in patients with laryngeal 
      squamous cell carcinoma (LSCC) and to investigate its diagnostic and prognostic 
      value.Materials and methods: We detected serum miR-632 levels in 162 LSCC 
      patients and 42 healthy volunteers. The ROC curve was carried out to determine 
      diagnostic accuracy.Results: We observed that serum miR-632 levels were 
      upregulated in LSCC patients compared with healthy volunteers (p < .01). 
      Subsequent results from ROC indicated that high sensitivity and specificity of 
      serum miR-632 for diagnosing LSCC (area under the curve 0.8828). In addition, it 
      was found that high expressions of serum miR-632 were significantly associated 
      with advanced N stage (p = .020), histological grade (p = .001), and TNM stage 
      (p = .014). Furthermore, patients with higher serum miR-632 expression had a 
      shorter OS and DFS time than those with lower serum miR-632 levels.Conclusion: 
      Our data revealed that serum miR-632 may be a potential noninvasive biomarker 
      which may become a potential diagnostic and prognostic biomarker for LSCC 
      patients.
FAU - Cao, Ying-Chun
AU  - Cao YC
AUID- ORCID: 0000-0001-6717-584X
AD  - Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
FAU - Song, Li-Qiang
AU  - Song LQ
AD  - Department of Oncology, Dongying People's Hospital, Dongying, China.
FAU - Xu, Wei-Wei
AU  - Xu WW
AD  - Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
FAU - Qi, Jun-Jun
AU  - Qi JJ
AD  - Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
FAU - Wang, Xiang-Yun
AU  - Wang XY
AD  - Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
FAU - Su, Yi
AU  - Su Y
AD  - Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
LA  - eng
PT  - Journal Article
DEP - 20200218
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN632 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor/blood
MH  - Carcinoma, Squamous Cell/*blood/diagnosis/mortality
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/diagnosis/mortality
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
OTO - NOTNLM
OT  - Serum miR-632
OT  - diagnosis
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
EDAT- 2020/02/19 06:00
MHDA- 2021/02/10 06:00
CRDT- 2020/02/19 06:00
PHST- 2020/02/19 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/02/19 06:00 [entrez]
AID - 10.1080/00016489.2020.1717610 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2020 May;140(5):418-421. doi: 10.1080/00016489.2020.1717610. 
      Epub 2020 Feb 18.