PMID- 32069757
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 182
DP  - 2020 Mar
TI  - Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 
      6 months.
PG  - 109122
LID - S0013-9351(20)30013-X [pii]
LID - 10.1016/j.envres.2020.109122 [doi]
AB  - BACKGROUND: Exposure to mixture of neurotoxic metals such as lead, mercury and 
      cadmium occurs at a specific point of time. When exposed to metal mixtures, one 
      metal may act as an agonist or antagonist to another metal. Thus, it is important 
      to study the effects of exposure to a combination of metals on children's 
      development using advance statistical methods. OBJECTIVES: In this study, we 
      explored the effects of prenatal metal exposure including lead, mercury and 
      cadmium in early pregnancy (12-20 weeks), late pregnancy (>28 weeks), and at 
      birth on neurodevelopment of infants at 6 months of age. METHODS: We included 523 
      eligible mother-child pairs from the mothers and children environmental health 
      (MOCEH) study, a prospective birth cohort study in Korea. We used linear 
      regression, Bayesian kernel machine regression (BKMR) and generalized additive 
      models (GAM), to evaluate the effects of exposure to metal mixtures on 
      neurodevelopment of infants aged 6 months. The Korean version of Bayley scale of 
      infant and toddler development-II was used to measure the child's 
      neurodevelopment. RESULTS: Linear regression models showed a significant negative 
      effect of lead exposure during late pregnancy on the mental development index 
      (MDI) [beta = -2.51 (-4.92, -0.10)] scores of infants aged 6 months following 
      co-exposure to mercury. Further, linear regression analysis showed a significant 
      interaction between late pregnancy lead and mercury concentrations. BKMR analysis 
      showed similar results as those obtained in linear regression models. These 
      results were also replicated in the GAM. Stratification analysis showed that 
      greater than 50 percentile concentration of mercury in late pregnancy potentiated 
      the adverse effects of lead in late pregnancy on MDI [beta = -4.33 (-7.66, -1.00)] 
      and psychomotor development index (PDI) [beta = -5.30 (-9.13, -1.46)] at 6 months of 
      age. Prenatal cadmium exposure did not show a significant association with MDI 
      and PDI at 6 months in the linear regression or BKMR analysis. CONCLUSION: Based 
      on all the statistical methods used, we demonstrated the effect of combined 
      exposure to metals on the neurodevelopment of infants aged 6 months, with 
      significant interaction between lead and mercury.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Shah-Kulkarni, Surabhi
AU  - Shah-Kulkarni S
AD  - Department of Occupational and Environmental Medicine, Ewha Womans University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Seulbi
AU  - Lee S
AD  - Department of Occupational and Environmental Medicine, Ewha Womans University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Jeong, Kyoung Sook
AU  - Jeong KS
AD  - Department of Occupational and Environmental Medicine, Hallym University Sacred 
      Heart Hospital, Gyeonggido, Republic of Korea.
FAU - Hong, Yun-Chul
AU  - Hong YC
AD  - Department of Preventive Medicine, College of Medicine, Seoul National 
      University, Seoul, Republic of Korea.
FAU - Park, Hyesook
AU  - Park H
AD  - Department of Preventive Medicine, Ewha Womans University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Ha, Mina
AU  - Ha M
AD  - Department of Preventive Medicine, Dankook University College of Medicine, 
      Cheonan, Republic of Korea.
FAU - Kim, Yangho
AU  - Kim Y
AD  - Department of Occupational and Environmental Medicine, University of Ulsan 
      College of Medicine, Ulsan University Hospital, Ulsan, Republic of Korea.
FAU - Ha, Eun-Hee
AU  - Ha EH
AD  - Department of Occupational and Environmental Medicine, Ewha Womans University 
      College of Medicine, Seoul, Republic of Korea. Electronic address: 
      eunheeha@ewha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200108
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Bayes Theorem
MH  - *Child Development/drug effects
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Maternal Exposure
MH  - *Metals, Heavy/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
MH  - Republic of Korea
OTO - NOTNLM
OT  - Birth cohort study
OT  - Metal mixtures
OT  - Multiple pollutants
OT  - Neurodevelopment
EDAT- 2020/02/20 06:00
MHDA- 2020/09/10 06:00
CRDT- 2020/02/20 06:00
PHST- 2019/05/14 00:00 [received]
PHST- 2020/01/06 00:00 [revised]
PHST- 2020/01/06 00:00 [accepted]
PHST- 2020/02/20 06:00 [entrez]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
AID - S0013-9351(20)30013-X [pii]
AID - 10.1016/j.envres.2020.109122 [doi]
PST - ppublish
SO  - Environ Res. 2020 Mar;182:109122. doi: 10.1016/j.envres.2020.109122. Epub 2020 
      Jan 8.