PMID- 32069764
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20210616
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 182
DP  - 2020 Mar
TI  - Prenatal exposure to traffic and ambient air pollution and infant weight and 
      adiposity: The Healthy Start study.
PG  - 109130
LID - S0013-9351(20)30022-0 [pii]
LID - 10.1016/j.envres.2020.109130 [doi]
AB  - BACKGROUND: Prenatal exposures to ambient air pollution and traffic have been 
      associated with adverse birth outcomes, and may also lead to an increased risk of 
      obesity. Obesity risk may be reflected in changes in body composition in infancy. 
      OBJECTIVE: To estimate associations between prenatal ambient air pollution and 
      traffic exposure, and infant weight and adiposity in a Colorado-based prospective 
      cohort study. METHODS: Participants were 1125 mother-infant pairs with term 
      births. Birth weight was recorded from medical records and body composition 
      measures (fat mass, fat-free mass, and adiposity [percent fat mass]) were 
      evaluated via air displacement plethysmography at birth (n = 951) and at ~5 
      months (n = 574). Maternal residential address was used to calculate distance to 
      nearest roadway, traffic density, and ambient concentrations of fine particulate 
      matter (PM(2.5)) and ozone (O(3)) via inverse-distance weighted interpolation of 
      stationary monitoring data, averaged by trimester and throughout pregnancy. 
      Adjusted linear regression models estimated associations between exposures and 
      infant weight and body composition. RESULTS: Participants were urban residents 
      and diverse in race/ethnicity and socioeconomic status. Average ambient air 
      pollutant concentrations were generally low; the median, interquartile range 
      (IQR), and range of third trimester concentrations were 7.3 mug/m(3) (IQR: 1.3, 
      range: 3.3-12.7) for PM(2.5) and 46.3 ppb (IQR: 18.4, range: 21.7-63.2) for 8-h 
      maximum O(3.) Overall there were few associations between traffic and air 
      pollution exposures and infant outcomes. Third trimester O(3) was associated with 
      greater adiposity at follow-up (2.2% per IQR, 95% CI 0.1, 4.3), and with greater 
      rates of change in fat mass (1.8 g/day, 95% CI 0.5, 3.2) and adiposity (2.1%/100 
      days, 95% CI 0.4, 3.7) from birth to follow-up. CONCLUSIONS: We found limited 
      evidence of an association between prenatal traffic and ambient air pollution 
      exposure and infant body composition. Suggestive associations between prenatal 
      ozone exposure and early postnatal changes in body composition merit further 
      investigation.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Starling, Anne P
AU  - Starling AP
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA. Electronic address: anne.starling@cuanschutz.edu.
FAU - Moore, Brianna F
AU  - Moore BF
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA.
FAU - Thomas, Deborah S K
AU  - Thomas DSK
AD  - Department of Geography and Earth Sciences, University of North Carolina 
      Charlotte, NC, USA.
FAU - Peel, Jennifer L
AU  - Peel JL
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA.
FAU - Zhang, Weiming
AU  - Zhang W
AD  - Department of Biostatistics and Informatics, Colorado School of Public Health, 
      University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Adgate, John L
AU  - Adgate JL
AD  - Department of Environmental and Occupational Health, Colorado School of Public 
      Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Magzamen, Sheryl
AU  - Magzamen S
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA; Department of Epidemiology, Colorado School of 
      Public Health, Colorado State University, Fort Collins, CO, USA.
FAU - Martenies, Sheena E
AU  - Martenies SE
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA.
FAU - Allshouse, William B
AU  - Allshouse WB
AD  - Department of Environmental and Occupational Health, Colorado School of Public 
      Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Dabelea, Dana
AU  - Dabelea D
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University 
      of Colorado Anschutz Medical Campus, Aurora, CO, USA.
LA  - eng
GR  - P30 DK048520/DK/NIDDK NIH HHS/United States
GR  - R00 ES025817/ES/NIEHS NIH HHS/United States
GR  - R01 DK076648/DK/NIDDK NIH HHS/United States
GR  - UH3 OD023248/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200110
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - *Adiposity
MH  - *Air Pollutants/toxicity
MH  - *Air Pollution
MH  - *Birth Weight
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Obesity
MH  - Particulate Matter
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
MH  - *Vehicle Emissions/toxicity
PMC - PMC7394733
MID - NIHMS1608651
OTO - NOTNLM
OT  - Adiposity
OT  - Air pollution
OT  - Infant
OT  - Pregnancy
OT  - Traffic
COIS- Declaration of competing interest The authors state that they have no competing 
      financial interests related to this work.
EDAT- 2020/02/20 06:00
MHDA- 2020/09/10 06:00
PMCR- 2021/03/01
CRDT- 2020/02/20 06:00
PHST- 2019/10/04 00:00 [received]
PHST- 2020/01/08 00:00 [revised]
PHST- 2020/01/09 00:00 [accepted]
PHST- 2020/02/20 06:00 [entrez]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - S0013-9351(20)30022-0 [pii]
AID - 10.1016/j.envres.2020.109130 [doi]
PST - ppublish
SO  - Environ Res. 2020 Mar;182:109130. doi: 10.1016/j.envres.2020.109130. Epub 2020 
      Jan 10.