PMID- 32070136
OWN - NLM
STAT- MEDLINE
DCOM- 20211216
LR  - 20211216
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
VI  - 100
IP  - 5_suppl
DP  - 2021 Sep
TI  - The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With 
      Allergic Rhinitis.
PG  - 712S-719S
LID - 10.1177/0145561320907172 [doi]
AB  - Korean red ginseng (KRG) has been traditionally used in Korea for health 
      improvement. However, the clinical effect of KRG intake on the symptoms in 
      patients with allergic rhinitis remains unknown. Our study was performed to 
      identify the clinical effects of KRG on patients with allergic rhinitis and to 
      examine the effect of KRG on allergic inflammatory reaction. We evaluated 60 
      patients with allergic rhinitis. All the patients were treated for 4 weeks. The 
      patients were divided into 3 groups, according to the medication. Twenty patients 
      were treated with KRG, 20 patients with the placebo, and 20 patients with the 
      antihistamine. The patients recorded their symptoms in a daily symptom diary 
      card. The patients checked the peak nasal inspiratory flow rate 2 times a day. 
      Total serum immunoglobulin E (IgE) and serum-specific IgE were measured by 
      ImmunoCap method before and after 4-week medication. The Th2 cytokines 
      interleukin-4 (IL-4), IL-5, and IL-10 were checked in the serum before and after 
      the 4-week treatment. The eosinophil counts in the nasal smears were checked. 
      Korean red ginseng group has shown the significant improvement in rhinorrhea, 
      nasal itching, and eye itching. Both the antihistamine and KRG groups showed a 
      significant decrease in total IgE level at the end of treatment. The serum IL-4 
      level and eosinophil counts in the nasal smears were significantly decreased both 
      in the antihistamine and in the KRG groups. In conclusion, KRG might be a useful 
      treatment modality for patients with allergic rhinitis.
FAU - Jung, Joo Hyun
AU  - Jung JH
AD  - Department of Otolaryngology, Gil Medical Center, College of Medicine, 
      65437Gachon University, Incheon, Korea.
FAU - Kang, Tae Kyu
AU  - Kang TK
AUID- ORCID: 0000-0002-7274-0476
AD  - Department of Otolaryngology, Gil Medical Center, College of Medicine, 
      65437Gachon University, Incheon, Korea.
FAU - Oh, Jae Hwan
AU  - Oh JH
AD  - Department of Otolaryngology, Gil Medical Center, College of Medicine, 
      65437Gachon University, Incheon, Korea.
FAU - Jeong, Jin Uk
AU  - Jeong JU
AD  - Department of Otolaryngology, Gil Medical Center, College of Medicine, 
      65437Gachon University, Incheon, Korea.
FAU - Ko, Kwang Pil
AU  - Ko KP
AD  - Department of Preventive Medicine, College of Medicine, 65437Gachon University, 
      Incheon, Korea.
FAU - Kim, Seon Tae
AU  - Kim ST
AUID- ORCID: 0000-0002-2010-2843
AD  - Department of Otolaryngology, Gil Medical Center, College of Medicine, 
      65437Gachon University, Incheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200219
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
RN  - 0 (Cytokines)
RN  - 0 (Histamine Antagonists)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Abdominal Pain/chemically induced
MH  - Adult
MH  - Cytokines/blood
MH  - Eosinophils
MH  - Female
MH  - Histamine Antagonists/adverse effects/therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Nausea/chemically induced
MH  - *Panax/adverse effects
MH  - Plant Extracts/adverse effects/*therapeutic use
MH  - Pulmonary Ventilation
MH  - Rhinitis, Allergic/*drug therapy/immunology
OTO - NOTNLM
OT  - Korean red ginseng
OT  - allergic rhinitis
OT  - cytokines
OT  - ginsenoside
EDAT- 2020/02/20 06:00
MHDA- 2021/12/17 06:00
CRDT- 2020/02/20 06:00
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2021/12/17 06:00 [medline]
PHST- 2020/02/20 06:00 [entrez]
AID - 10.1177/0145561320907172 [doi]
PST - ppublish
SO  - Ear Nose Throat J. 2021 Sep;100(5_suppl):712S-719S. doi: 
      10.1177/0145561320907172. Epub 2020 Feb 19.