PMID- 32070305
OWN - NLM
STAT- MEDLINE
DCOM- 20201218
LR  - 20210110
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Feb 18
TI  - Diacron reactive oxygen metabolites and biological antioxidant potential tests 
      for patients with age-related macular degeneration.
PG  - 56
LID - 10.1186/s12886-020-01334-y [doi]
LID - 56
AB  - BACKGROUND: Previously, we showed that serum malondialdehyde (MDA) was 
      significantly higher in patients with neovascular age-related macular 
      degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen 
      metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known 
      markers of oxidative stress. The aim of this study was to use d-ROMs and BAP 
      tests to evaluate changes in systemic oxidative stress in patients with nAMD. 
      METHODS: Blood serum samples were collected from 34 patients with nAMD (mean age: 
      76.5 +/- 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 +/- 14.0 years; 
      10 men), and d-ROMs and BAP tests were examined. RESULTS: In men, the mean level 
      of d-ROMs for the nAMD patients was significantly higher than that for the 
      controls (312.0 +/- 52.4 vs. 275.1 +/- 45.5 U.CARR, respectively; P < .05). There was 
      a significant correlation between d-ROM level and CNV lesion area in the male 
      nAMD group (r = .42, P = .05). There were no significant differences in mean BAP 
      test results between the nAMD patients and controls for either sex (men: 
      2241 +/- 549 vs. 2136 +/- 246 mumol/L; women: 2263 +/- 292 vs. 2335 +/- 161 mumol/L). 
      CONCLUSION: The d-ROMs test may provide a useful indicator of nAMD in men but not 
      in women.
FAU - Matsuura, Toshiyuki
AU  - Matsuura T
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Kaneko, Hiroki
AU  - Kaneko H
AUID- ORCID: 0000-0003-0731-6465
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. h-kaneko@med.nagoya-u.ac.jp.
FAU - Takayama, Kei
AU  - Takayama K
AD  - Department of Ophthalmology, National Defense Medical College, Saitama, Japan.
FAU - Shibata, Rei
AU  - Shibata R
AD  - Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate 
      School of Medicine, Nagoya, Japan.
FAU - Kataoka, Keiko
AU  - Kataoka K
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Ito, Seina
AU  - Ito S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Tsunekawa, Taichi
AU  - Tsunekawa T
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Shimizu, Hideyuki
AU  - Shimizu H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Suzumura, Ayana
AU  - Suzumura A
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Namba, Rina
AU  - Namba R
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Ito, Yasuki
AU  - Ito Y
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Murohara, Toyoaki
AU  - Murohara T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Terasaki, Hiroko
AU  - Terasaki H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
LA  - eng
GR  - 17K16964/Grants-in-Aid for Young Scientist B/
GR  - n/a/Japan Foundation for Applied Enzymology/
GR  - n/a/The Eye Research Foundation for the Aged (ERFA)/
GR  - n/a/Takeda Science Foundation/
PT  - Journal Article
DEP - 20200218
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Biomarkers/*blood
MH  - Choroidal Neovascularization/*blood/diagnosis
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/*blood
MH  - Visual Acuity/physiology
MH  - Wet Macular Degeneration/*blood/diagnosis
PMC - PMC7027115
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Biological antioxidant potential
OT  - Choroidal neovascularization
OT  - Diacron reactive oxygen metabolites
OT  - Oxidative stress
COIS- The authors declare that they have no competing interests.
EDAT- 2020/02/20 06:00
MHDA- 2020/12/19 06:00
PMCR- 2020/02/18
CRDT- 2020/02/20 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/02/20 06:00 [entrez]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2020/12/19 06:00 [medline]
PHST- 2020/02/18 00:00 [pmc-release]
AID - 10.1186/s12886-020-01334-y [pii]
AID - 1334 [pii]
AID - 10.1186/s12886-020-01334-y [doi]
PST - epublish
SO  - BMC Ophthalmol. 2020 Feb 18;20(1):56. doi: 10.1186/s12886-020-01334-y.