PMID- 32070665 OWN - NLM STAT- MEDLINE DCOM- 20210817 LR - 20210817 IS - 1878-0210 (Electronic) IS - 1878-0210 (Linking) VI - 14 IP - 5 DP - 2020 Oct TI - Association between mean arterial pressure and risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study. PG - 448-454 LID - S1751-9918(19)30278-5 [pii] LID - 10.1016/j.pcd.2020.01.007 [doi] AB - AIMS: Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults. METHODS: We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose-response association between MAP and risk of T2DM. RESULTS: During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90-100mmHg) and fourth MAP categories (>/=100mmHg) than the first category (<80mmHg) after adjusting for confounders (HR=1.74 [95% CI 1.14-2.68] and 1.84 [1.20-2.83]). Restricted cubic spline analysis revealed increased risk of T2DM with increasing MAP for women. CONCLUSION: High MAP was related to high incident T2DM among women in China. CI - Copyright (c) 2020 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. FAU - Guo, Chunmei AU - Guo C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Qin, Pei AU - Qin P AD - Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Li, Quanman AU - Li Q AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Dongdong AU - Zhang D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Tian, Gang AU - Tian G AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Liu, Dechen AU - Liu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Liu, Leilei AU - Liu L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Cheng, Cheng AU - Cheng C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Chen, Xu AU - Chen X AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Qie, Ranran AU - Qie R AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Han, Minghui AU - Han M AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Huang, Shengbing AU - Huang S AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhou, Qionggui AU - Zhou Q AD - Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Liu, Feiyan AU - Liu F AD - Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wu, Xiaoyan AU - Wu X AD - Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Ren, Yongcheng AU - Ren Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Liu, Yu AU - Liu Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Sun, Xizhuo AU - Sun X AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Li, Honghui AU - Li H AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wang, Bingyuan AU - Wang B AD - The Central China Fuwai Cardiovascular Research Center, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Ming AU - Zhang M AD - Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Lu, Jie AU - Lu J AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: hanyaa800@zzu.edu.cn. FAU - Hu, Dongsheng AU - Hu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: dongshenghu563@126.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200215 PL - England TA - Prim Care Diabetes JT - Primary care diabetes JID - 101463825 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Arterial Pressure MH - China/epidemiology MH - Diabetes Mellitus, Type 2/diagnosis/*epidemiology MH - Female MH - Humans MH - Hypertension/diagnosis/*epidemiology/physiopathology MH - Incidence MH - Male MH - Middle Aged MH - Risk Assessment MH - Risk Factors MH - *Rural Health MH - Sex Factors MH - Young Adult OTO - NOTNLM OT - Cohort study OT - Mean arterial pressure OT - Type 2 diabetes mellitus EDAT- 2020/02/20 06:00 MHDA- 2021/08/18 06:00 CRDT- 2020/02/20 06:00 PHST- 2019/06/24 00:00 [received] PHST- 2019/12/13 00:00 [revised] PHST- 2020/01/23 00:00 [accepted] PHST- 2020/02/20 06:00 [pubmed] PHST- 2021/08/18 06:00 [medline] PHST- 2020/02/20 06:00 [entrez] AID - S1751-9918(19)30278-5 [pii] AID - 10.1016/j.pcd.2020.01.007 [doi] PST - ppublish SO - Prim Care Diabetes. 2020 Oct;14(5):448-454. doi: 10.1016/j.pcd.2020.01.007. Epub 2020 Feb 15.