PMID- 32070692
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20210326
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 112
DP  - 2020 May
TI  - Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's 
      disease-related pathology.
PG  - 634-647
LID - S0149-7634(19)30469-5 [pii]
LID - 10.1016/j.neubiorev.2020.02.012 [doi]
AB  - Transgenic mouse models have been used extensively to model the cognitive 
      impairments arising from Alzheimer's disease (AD)-related pathology. However, 
      less is known about the relationship between AD-related pathology and the 
      behavioural and psychological symptoms of dementia (BPSD) commonly presented by 
      patients. This review discusses the BPSD-like behaviours recapitulated by several 
      mouse models of AD-related pathology, including the APP/PS1, Tg2576, 3xTg-AD, 
      5xFAD, and APP23 models. Current evidence suggests that social withdrawal and 
      depressive-like behaviours increase with progressive neuropathology, and 
      increased aggression and sleep-wake disturbances are present even at early 
      stages; however, there is no clear evidence to support increased anxiety-like 
      behaviours, agitation (hyperactivity), or general apathy. Overall, transgenic 
      mouse models of AD-related pathology recapitulate some of the BPSD-like 
      behaviours associated with AD, but these behaviours vary by model. This reflects 
      the patient population, where AD patients typically exhibit one or more BPSD, but 
      rarely all symptoms at once. As a result, we suggest that transgenic mouse models 
      are an important tool to investigate the pathology underlying BPSD in human AD 
      patients.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Kosel, Filip
AU  - Kosel F
AD  - The Social Lab, Department of Psychology and Neuroscience, Dalhousie University, 
      Halifax, B3H 4R2, Canada.
FAU - Pelley, Jessica M S
AU  - Pelley JMS
AD  - The Social Lab, Department of Psychology and Neuroscience, Dalhousie University, 
      Halifax, B3H 4R2, Canada.
FAU - Franklin, Tamara B
AU  - Franklin TB
AD  - The Social Lab, Department of Psychology and Neuroscience, Dalhousie University, 
      Halifax, B3H 4R2, Canada. Electronic address: tamara.franklin@dal.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200215
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - Alzheimer Disease/*physiopathology/*psychology
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - *Disease Models, Animal
MH  - Mice
MH  - Mice, Transgenic
MH  - *Social Behavior
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid
OT  - Behavioral and psychological symptoms of dementia (BPSD)
OT  - Mouse models
OT  - Neuropsychiatric symptoms (NPS)
OT  - Social behaviours
OT  - Tau
EDAT- 2020/02/20 06:00
MHDA- 2021/03/27 06:00
CRDT- 2020/02/20 06:00
PHST- 2019/06/25 00:00 [received]
PHST- 2020/02/08 00:00 [revised]
PHST- 2020/02/11 00:00 [accepted]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/02/20 06:00 [entrez]
AID - S0149-7634(19)30469-5 [pii]
AID - 10.1016/j.neubiorev.2020.02.012 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2020 May;112:634-647. doi: 
      10.1016/j.neubiorev.2020.02.012. Epub 2020 Feb 15.