PMID- 32071254
OWN - NLM
STAT- MEDLINE
DCOM- 20210810
LR  - 20210810
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 27
IP  - 3
DP  - 2020 Mar
TI  - Phasic signaling in the bed nucleus of the stria terminalis during fear learning 
      predicts within- and across-session cued fear expression.
PG  - 83-90
LID - 10.1101/lm.050807.119 [doi]
AB  - While results from many past studies have implicated the bed nucleus of the stria 
      terminalis (BNST) in mediating the expression of sustained negative affect, 
      recent studies have highlighted a more complex role for BNST that includes 
      aspects of fear learning in addition to defensive responding. As BNST is thought 
      to encode ambiguous or unpredictable threat, it seems plausible that it may be 
      involved in encoding early cued fear learning, especially immediately following a 
      first tone-shock pairing when the conditioned stimulus-unconditioned stimulus 
      (CS-US) contingency is not fully apparent. To investigate this, we conducted in 
      vivo electrophysiological recording studies to examine neural dynamics of BNST 
      units during cued fear acquisition and recall. We identified two functionally 
      distinct subpopulations of BNST neurons that encode the intertrial interval (ITI) 
      and may contribute to within- and across-session fear learning. "Ramping" cell 
      activity during cued fear acquisition parallels the increase in freezing 
      expression as mice learn the CS-US contingency, while "Phasic" cells encode 
      postshock (US(post)) periods (30 sec following encounter with footshock) only 
      during early trials. Importantly, the magnitude of Phasic unit responsivity to 
      the first US(post) period predicted not only freezing expression in response to 
      the subsequent CS during acquisition, but also CS freezing evoked 24 h later 
      during CS retrieval. These findings suggest for the first time that BNST activity 
      may serve as an instructive signal during cued fear learning.
CI  - (c) 2020 Bjorni et al.; Published by Cold Spring Harbor Laboratory Press.
FAU - Bjorni, Max
AU  - Bjorni M
AD  - Department of Psychology, Santa Clara University, Santa Clara, California 95053, 
      USA.
FAU - Rovero, Natalie G
AU  - Rovero NG
AD  - Department of Psychology, Santa Clara University, Santa Clara, California 95053, 
      USA.
FAU - Yang, Elissa R
AU  - Yang ER
AD  - Department of Psychology, Santa Clara University, Santa Clara, California 95053, 
      USA.
FAU - Holmes, Andrew
AU  - Holmes A
AD  - Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol 
      Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, 
      USA.
FAU - Halladay, Lindsay R
AU  - Halladay LR
AUID- ORCID: 0000-0003-2232-6709
AD  - Department of Psychology, Santa Clara University, Santa Clara, California 95053, 
      USA.
AD  - Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol 
      Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200218
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Conditioning, Classical/*physiology
MH  - *Cues
MH  - Electroencephalography
MH  - Electrophysiological Phenomena/*physiology
MH  - Fear/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Septal Nuclei/*physiology
PMC - PMC7029722
EDAT- 2020/02/20 06:00
MHDA- 2021/08/11 06:00
PMCR- 2021/03/01
CRDT- 2020/02/20 06:00
PHST- 2019/09/08 00:00 [received]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2020/02/20 06:00 [entrez]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2021/08/11 06:00 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 27/3/83 [pii]
AID - LM050807Bjo [pii]
AID - 10.1101/lm.050807.119 [doi]
PST - epublish
SO  - Learn Mem. 2020 Feb 18;27(3):83-90. doi: 10.1101/lm.050807.119. Print 2020 Mar.