PMID- 32073177
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20240328
IS  - 1573-6598 (Electronic)
IS  - 0894-9867 (Print)
IS  - 0894-9867 (Linking)
VI  - 33
IP  - 2
DP  - 2020 Apr
TI  - Posttraumatic Growth After MDMA-Assisted Psychotherapy for Posttraumatic Stress 
      Disorder.
PG  - 161-170
LID - 10.1002/jts.22479 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic 
      stress disorder (PTSD) has been shown to significantly reduce clinical 
      symptomatology, but posttraumatic growth (PTG), which consists of positive 
      changes in self-perception, interpersonal relationships, or philosophy of life, 
      has not been studied with this treatment. Participant data (n = 60) were pooled 
      from three Phase 2 clinical studies employing triple-blind crossover designs. 
      Participants were required to meet DSM-IV-R criteria for PTSD with a score higher 
      than 50 on the Clinician-Administered PTSD Scale (CAPS-IV) as well as previous 
      inadequate response to pharmacological and/or psychotherapeutic treatment. Data 
      were aggregated into two groups: an active MDMA dose group (75-125 mg of MDMA; n 
      = 45) or placebo/active control (0-40 mg of MDMA; n = 15). Measures included the 
      Posttraumatic Growth Inventory (PTGI) and the CAPS-IV, which were administered at 
      baseline, primary endpoint, treatment exit, and 12-month follow-up. At primary 
      endpoint, the MDMA group demonstrated more PTG, Hedges' g = 1.14, 95% CI [0.49, 
      1.78], p < .001; and a larger reduction in PTSD symptom severity, Hedges' g = 
      0.88, 95% CI [-0.28, 1.50], p < .001, relative to the control group. Relative to 
      baseline, at the 12-month follow-up, within-subject PTG was higher, p < .001; 
      PTSD symptom severity scores were lower, p < .001; and two-thirds of participants 
      (67.2%) no longer met criteria for PTSD. MDMA-assisted psychotherapy for PTSD 
      resulted in PTG and clinical symptom reductions of large-magnitude effect sizes. 
      Results suggest that PTG may provide a new mechanism of action warranting further 
      study.
CI  - (c) 2020 Multidisciplinary Association for Psychedelic Studies, Inc. Journal of 
      Traumatic Stress published by Wiley Periodicals, Inc. on behalf of International 
      Society for Traumatic Stress Studies.
FAU - Gorman, Ingmar
AU  - Gorman I
AD  - Rory Meyers College of Nursing, New York University, New York, New York, USA.
FAU - Belser, Alexander B
AU  - Belser AB
AD  - School of Medicine, Yale University, New Haven, Connecticut, USA.
FAU - Jerome, Lisa
AU  - Jerome L
AD  - MAPS Public Benefit Corporation, Santa Cruz, California, USA.
FAU - Hennigan, Colin
AU  - Hennigan C
AD  - MAPS Public Benefit Corporation, Santa Cruz, California, USA.
FAU - Shechet, Ben
AU  - Shechet B
AD  - Scottsdale Research Institute, Phoenix, Arizona, USA.
FAU - Hamilton, Scott
AU  - Hamilton S
AD  - Stanford University School of Medicine, Stanford University, Stanford, 
      California, USA.
FAU - Yazar-Klosinski, Berra
AU  - Yazar-Klosinski B
AD  - Multidisciplinary Association for Psychedelic Studies, Santa Cruz, California, 
      USA.
FAU - Emerson, Amy
AU  - Emerson A
AD  - MAPS Public Benefit Corporation, Santa Cruz, California, USA.
FAU - Feduccia, Allison A
AU  - Feduccia AA
AD  - MAPS Public Benefit Corporation, Santa Cruz, California, USA.
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200219
PL  - United States
TA  - J Trauma Stress
JT  - Journal of traumatic stress
JID - 8809259
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Non-Randomized Controlled Trials as Topic
MH  - Posttraumatic Growth, Psychological/*drug effects
MH  - Psychotherapy/methods
MH  - Severity of Illness Index
MH  - Stress Disorders, Post-Traumatic/*therapy
PMC - PMC7216948
EDAT- 2020/02/20 06:00
MHDA- 2021/03/27 06:00
PMCR- 2020/05/12
CRDT- 2020/02/20 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/08/09 00:00 [revised]
PHST- 2019/08/15 00:00 [accepted]
PHST- 2020/02/20 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/02/20 06:00 [entrez]
PHST- 2020/05/12 00:00 [pmc-release]
AID - JTS22479 [pii]
AID - 10.1002/jts.22479 [doi]
PST - ppublish
SO  - J Trauma Stress. 2020 Apr;33(2):161-170. doi: 10.1002/jts.22479. Epub 2020 Feb 
      19.