PMID- 32074956
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20240328
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 4
DP  - 2020 Feb 14
TI  - The Vitamin A and D Exposure of Cells Affects the Intracellular Uptake of 
      Aluminum Nanomaterials and its Agglomeration Behavior: A Chemo-Analytic 
      Investigation.
LID - 10.3390/ijms21041278 [doi]
LID - 1278
AB  - Aluminum (Al) is extensively used for the production of different consumer 
      products, agents, as well as pharmaceuticals. Studies that demonstrate 
      neurotoxicity and a possible link to Alzheimer's disease trigger concern about 
      potential health risks due to high Al intake. Al in cosmetic products raises the 
      question whether a possible interaction between Al and retinol (vitamin A) and 
      cholecalciferol (vitamin D3) metabolism might exist. Understanding the uptake 
      mechanisms of ionic or elemental Al and Al nanomaterials (Al NMs) in combination 
      with bioactive substances are important for the assessment of possible health 
      risk associated. Therefore, we studied the uptake and distribution of Al oxide 
      (Al(2)O(3)) and metallic Al(0) NMs in the human keratinocyte cell line HaCaT. 
      Possible alterations of the metabolic pattern upon application of the two Al 
      species together with vitamin A or D3 were investigated. Time-of-flight secondary 
      ion mass spectrometry (ToF-SIMS) imaging and inductively coupled plasma mass 
      spectrometry (ICP-MS) were applied to quantify the cellular uptake of Al NMs.
FAU - Kriegel, Fabian L
AU  - Kriegel FL
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Reichardt, Philipp
AU  - Reichardt P
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Krause, Benjamin-Christoph
AU  - Krause BC
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Singh, Ajay Vikram
AU  - Singh AV
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Tentschert, Jutta
AU  - Tentschert J
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Laux, Peter
AU  - Laux P
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Jungnickel, Harald
AU  - Jungnickel H
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
FAU - Luch, Andreas
AU  - Luch A
AD  - German Federal Institute for Risk Assessment, Department of Chemical & Product 
      Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200214
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 11103-57-4 (Vitamin A)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - CPD4NFA903 (Aluminum)
RN  - LMI26O6933 (Aluminum Oxide)
SB  - IM
MH  - Aluminum/*analysis/chemistry/metabolism
MH  - Aluminum Oxide/*analysis/chemistry/metabolism
MH  - Cell Line
MH  - Cell Membrane/chemistry/metabolism
MH  - Cholecalciferol/*pharmacology
MH  - Humans
MH  - Keratinocytes/cytology/drug effects/metabolism
MH  - Nanostructures/*chemistry
MH  - Spectrometry, Mass, Secondary Ion
MH  - Vitamin A/*pharmacology
PMC - PMC7072912
OTO - NOTNLM
OT  - ICP-MS
OT  - ToF-SIMS
OT  - aluminum
OT  - metabolomics
OT  - nanoparticle uptake
OT  - vitamin
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/23 06:00
MHDA- 2020/11/21 06:00
PMCR- 2020/02/01
CRDT- 2020/02/21 06:00
PHST- 2019/12/17 00:00 [received]
PHST- 2020/02/07 00:00 [revised]
PHST- 2020/02/12 00:00 [accepted]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - ijms21041278 [pii]
AID - ijms-21-01278 [pii]
AID - 10.3390/ijms21041278 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Feb 14;21(4):1278. doi: 10.3390/ijms21041278.