PMID- 32075751
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 34
IP  - 5
DP  - 2020 May
TI  - Mineralocorticoids, glucose homeostasis and type 2 diabetes mellitus: The Henan 
      Rural Cohort study.
PG  - 107558
LID - S1056-8727(19)31211-5 [pii]
LID - 10.1016/j.jdiacomp.2020.107558 [doi]
AB  - AIMS: We aimed to evaluate the associations of mineralocorticoids with type 2 
      diabetes mellitus (T2DM) and glucose homeostasis among rural Chinese adults. 
      METHODS: A total of 2713 participants were selected from the Henan Rural Cohort 
      study. Serum mineralocorticoids were measured by liquid chromatography-tandem 
      mass spectrometry. Logistic regression and restricted cubic splines were employed 
      to evaluate the associations of mineralocorticoids with pre-diabetes and T2DM. 
      Linear regression was implemented to assess the associations of aldosterone and 
      11-deoxycorticosterone with different markers of glucose homeostasis by different 
      diabetes status. RESULTS: Elevated aldosterone and 11-deoxycorticosterone were 
      associated with an increased prevalence of pre-diabetes and T2DM (P < 0.05), with 
      a nonlinear dose-response trend, but the association between 
      11-deoxycorticosterone and T2DM was no statistical significance after adjustment. 
      A 100% increase in ln-aldosterone was associated with a 0.029 mg/dl higher 
      fasting plasma glucose (FPG) and a 1.2% higher HOMA2-IR among those with normal 
      glucose tolerance (NGT), and related to a 0.034 mg/dl lower FPG, a 1.1% higher 
      HbA1c and a 1.3% higher HOMA2-beta among individuals with pre-diabetes. A 100% 
      increment in ln-11-deoxycorticosterone was associated with a 16% increase in 
      HbA1c and a 5.6% decrease in HOMA2-beta in participants with T2DM. CONCLUSIONS: 
      Higher aldosterone and 11-deoxycorticosterone are associated with T2DM risk and 
      glucose homeostasis disorder among different diabetes status.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Wei, Dandan
AU  - Wei D
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Liu, Xue
AU  - Liu X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Jiang, Jingjing
AU  - Jiang J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Tu, Runqi
AU  - Tu R
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Qiao, Dou
AU  - Qiao D
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Ruiying
AU  - Li R
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Yikang
AU  - Wang Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Fan, Mengying
AU  - Fan M
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Yang, Xiu
AU  - Yang X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Zhang, Jinyu
AU  - Zhang J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Hou, Jian
AU  - Hou J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Huo, Wenqian
AU  - Huo W
AD  - Department of Occupational and Environmental Health Sciences, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Yu, Songcheng
AU  - Yu S
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Linlin
AU  - Li L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Mao, Zhenxing
AU  - Mao Z
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China. Electronic address: maozhr@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200208
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Mineralocorticoids)
RN  - 40GP35YQ49 (Desoxycorticosterone)
RN  - 4964P6T9RB (Aldosterone)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Aldosterone/*blood/metabolism
MH  - Biomarkers/blood/metabolism
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Desoxycorticosterone/*blood/metabolism
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology/metabolism/physiopathology
MH  - Female
MH  - Glucose/analysis/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Mineralocorticoids/blood/metabolism
MH  - Prediabetic State/blood/*epidemiology/metabolism/physiopathology
MH  - Prevalence
MH  - Risk Factors
MH  - Rural Population/statistics & numerical data
OTO - NOTNLM
OT  - 11-Deoxycorticosterone
OT  - Aldosterone
OT  - Fasting plasma glucose
OT  - Pre-diabetes
OT  - Type 2 diabetes mellitus
OT  - beta cell function
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/02/23 06:00
MHDA- 2021/09/21 06:00
CRDT- 2020/02/21 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2020/01/07 00:00 [revised]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
AID - S1056-8727(19)31211-5 [pii]
AID - 10.1016/j.jdiacomp.2020.107558 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2020 May;34(5):107558. doi: 
      10.1016/j.jdiacomp.2020.107558. Epub 2020 Feb 8.