PMID- 32076039
OWN - NLM
STAT- MEDLINE
DCOM- 20201112
LR  - 20210218
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Feb 19
TI  - Semi-quantitative versus quantitative assessments of late gadolinium enhancement 
      extent for predicting spontaneous ventricular tachyarrhythmia events in patients 
      with hypertrophic cardiomyopathy.
PG  - 2920
LID - 10.1038/s41598-020-59804-8 [doi]
LID - 2920
AB  - Extent of late gadolinium enhancement (LGE) quantified by cardiac magnetic 
      resonance was reportedly helpful for predicting the risk of ventricular 
      tachyarrhythmias (VTA) in hypertrophic cardiomyopathy (HCM) patients. However, 
      only a few data exist on the clinical implication of semi-quantitative assessment 
      LGE extent in this patient population. The extent of left ventricular (LV) LGE 
      was measured in 310 consecutive HCM patients using semi-quantitative (summing the 
      LV segments with LGE, spatial extent) and quantitative (calculating the LGE 
      volume percentage [vol% of LGE] against the total LV myocardial volume) methods, 
      respectively. LV LGE was detected in 255 (82%) patients, most frequently in the 
      mid-LV septum (n = 160, 52%). During the 49 +/- 45 month follow-up, spontaneous VTA 
      events were observed in 48 patients (16%) including aborted sudden cardiac death 
      (SCD), appropriate defibrillator shock, and non-sustained VTA. The extent of LGE 
      assessed by the two different methods showed a strong positive correlation 
      (Spearman's r = 0.63, P < 0.001). Moreover, there was a graded increase in the 
      rates of VTA with the LGE extent evaluated semi-quantitatively and 
      quantitatively. The extent of LGE was identified as an independent predictor of 
      VTA events and more extensive LGE (positive >/= 4 segments) significantly raised 
      the risk of VTA, irrespective of the presence of conventional risk factors for 
      SCD including family history, unexplained syncope, LV wall thickness >/=30 mm. The 
      extent of LGE, whether assessed by semi-quantitative or quantitative methods, was 
      closely associated with an increased risk of spontaneous VTA events in HCM 
      patients.
FAU - Park, Young Jun
AU  - Park YJ
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Park, Seung-Jung
AU  - Park SJ
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 
      orthovics@gmail.com.
FAU - Kim, Eun-Kyung
AU  - Kim EK
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Park, Kyoung Min
AU  - Park KM
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Lee, Sang-Cheol
AU  - Lee SC
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - On, Young Keun
AU  - On YK
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Kim, June Soo
AU  - Kim JS
AD  - Department of Medicine, Heart Vascular and Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200219
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*complications/diagnostic imaging
MH  - Electrocardiography
MH  - Female
MH  - Gadolinium/*chemistry
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Tachycardia, Ventricular/*complications/*diagnosis/diagnostic imaging
PMC - PMC7031259
COIS- The authors declare no competing interests.
EDAT- 2020/02/23 06:00
MHDA- 2020/11/13 06:00
PMCR- 2020/02/19
CRDT- 2020/02/21 06:00
PHST- 2019/09/14 00:00 [received]
PHST- 2020/01/31 00:00 [accepted]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/11/13 06:00 [medline]
PHST- 2020/02/19 00:00 [pmc-release]
AID - 10.1038/s41598-020-59804-8 [pii]
AID - 59804 [pii]
AID - 10.1038/s41598-020-59804-8 [doi]
PST - epublish
SO  - Sci Rep. 2020 Feb 19;10(1):2920. doi: 10.1038/s41598-020-59804-8.