PMID- 32076606
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20221207
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular 
      Hypertrophy in Patients with Type 2 Diabetes.
PG  - 5240153
LID - 10.1155/2020/5240153 [doi]
LID - 5240153
AB  - Several studies show that even a level of urine albumin/creatinine ratio (UACR) 
      within the normal range (below 30 mg/g) increases the risk of cardiovascular 
      diseases. We speculate that mildly increased UACR is related to left ventricular 
      hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM). In this 
      retrospective study, 317 patients with diabetes with normal UACR, of whom 62 had 
      LVH, were included. The associations between UACR and laboratory indicators, as 
      well as LVH, were examined using multivariate linear regression and logistic 
      regression, respectively. The diagnostic efficiency and the optimal cutoff point 
      of UACR for LVH were evaluated using the area under the receiver operating 
      characteristic curve (AUC) and Youden index. Our results showed that patients 
      with LVH had significantly higher UACR than those without LVH (P < 0.001). The 
      prevalence of LVH presented an upward trend with the elevation of UACR. UACR was 
      independently and positively associated with hemoglobin A1c (P < 0.001). UACR can 
      differentiate LVH (AUC = 0.682, 95% CI (0.602-0.760), P < 0.001). The optimal 
      cutoff point determined with the Youden index was UACR = 10.2 mg/g. When 
      categorized by this cutoff point, the odds ratio (OR) for LVH in patients in the 
      higher UACR group (10.2-30 mg/g) was 3.104 (95% CI: 1.557-6.188, P=0.001) 
      compared with patients in the lower UACR group (<10.2 mg/g). When UACR was 
      analyzed as a continuous variable, every double of increased UACR, the OR for LVH 
      was 1.511 (95% CI: 1.047-2.180, P=0.028). Overall, UACR below 30 mg/g is 
      associated with LVH in patients with T2DM. The optimal cutoff value of UACR for 
      identifying LVH in diabetes is 10 mg/g.
CI  - Copyright (c) 2020 Xiangkun Xie et al.
FAU - Xie, Xiangkun
AU  - Xie X
AUID- ORCID: 0000-0002-1585-8005
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
AD  - Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, 
      Guangzhou, China.
FAU - Peng, Zhengliang
AU  - Peng Z
AUID- ORCID: 0000-0002-7494-2637
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
AD  - EICU, The First Affiliated Hospital of University of South China, Hengyang, 
      Hunan, China.
FAU - Li, Hanlin
AU  - Li H
AUID- ORCID: 0000-0002-5118-6576
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Li, Dan
AU  - Li D
AUID- ORCID: 0000-0002-4861-0364
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 
      China.
FAU - Tu, Yan
AU  - Tu Y
AUID- ORCID: 0000-0001-7955-8485
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Bai, Yujia
AU  - Bai Y
AUID- ORCID: 0000-0001-6019-8010
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Huang, Xingfu
AU  - Huang X
AUID- ORCID: 0000-0002-1366-2869
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Lai, Wenyan
AU  - Lai W
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Zhan, Qiong
AU  - Zhan Q
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Zeng, Qingchun
AU  - Zeng Q
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
FAU - Xu, Dingli
AU  - Xu D
AUID- ORCID: 0000-0002-3193-4354
AD  - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang 
      Hospital, Southern Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200121
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Albumins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albumins
MH  - Albuminuria/blood/*complications
MH  - Cardiovascular Diseases/epidemiology
MH  - China
MH  - Creatinine/blood/*urine
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*complications
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Retrospective Studies
PMC - PMC6996706
COIS- The authors declare no conflicts of interest.
EDAT- 2020/02/23 06:00
MHDA- 2020/12/01 06:00
PMCR- 2020/01/21
CRDT- 2020/02/21 06:00
PHST- 2019/10/02 00:00 [received]
PHST- 2019/12/18 00:00 [revised]
PHST- 2019/12/23 00:00 [accepted]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/01/21 00:00 [pmc-release]
AID - 10.1155/2020/5240153 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Jan 21;2020:5240153. doi: 10.1155/2020/5240153. eCollection 
      2020.