PMID- 32077056
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 14
IP  - 4
DP  - 2020 Dec
TI  - Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous 
      Cell Carcinoma: a Brazilian Multicentre Study.
PG  - 899-908
LID - 10.1007/s12105-020-01142-2 [doi]
AB  - Data on the occurrence and clinicopathological characteristics of actinic 
      cheilitis (AC) and lip squamous cell carcinoma (LSCC) are well studied; however, 
      they are based on studies limited to a single centre. Herein, we described the 
      frequency of AC and LSCC submitted to microscopic examination from representative 
      geographic regions of Brazil. A retrospective multicentre study was performed on 
      biopsies obtained from 1953 to 2018 at 10 Brazilian oral and maxillofacial 
      pathology centres. A total of 198,709 biopsy specimens were surveyed. 
      Sociodemographic data and clinicopathologic characteristics were analysed. A 
      total of 2017 cases of ACs (1.0%) and 850 cases of LSCCs (0.4%) were recorded. A 
      strong fair-skinned (> 87%) male (> 70%) predilection was observed in both 
      conditions. The mean age was 54.8 +/- 18.7 for individuals with AC and 57.8 +/- 19.0 
      for individuals with LSCC. The most commonly affected site was the lower lip 
      (> 90%). This is a large multicentre study of AC and LSCC from Brazil. The 
      frequency and clinicopathological features of AC and LSCC were similar to those 
      described worldwide. This study provides robust and representative 
      epidemiological data of these conditions for the scientific community.
FAU - Silva, Leni Veronica de Oliveira
AU  - Silva LVO
AUID- ORCID: 0000-0003-0336-9359
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brazil. 
      veronica.oliveira.3162@hotmail.com.
AD  - Departamento de Clinica, Patologia e Cirurgias Odontologicas, Faculdade de 
      Odontologia, Universidade Federal de Minas Gerais, Av. Presidente Antonio Carlos, 
      6627, sala 3202 D. Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil. 
      veronica.oliveira.3162@hotmail.com.
FAU - de Arruda, Jose Alcides Almeida
AU  - de Arruda JAA
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Abreu, Lucas Guimaraes
AU  - Abreu LG
AD  - Department of Paediatric Dentistry and Orthodontics, School of Dentistry, 
      Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Ferreira, Raquel Conceicao
AU  - Ferreira RC
AD  - Department of Social and Preventive Dentistry, School of Dentistry, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - da Silva, Leorik Pereira
AU  - da Silva LP
AD  - Postgraduate Program in Oral Pathology, School of Dentistry, Universidade Federal 
      do Rio Grande do Norte, Natal, RN, Brazil.
FAU - Pelissari, Cibele
AU  - Pelissari C
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade 
      de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Silva, Ricardo Nata Fonseca
AU  - Silva RNF
AD  - Department of Stomatology (Oral Pathology), School of Dentistry, Universidade 
      Federal de Goias, Goiania, GO, Brazil.
FAU - Nobrega, Kaio Heide Sampaio
AU  - Nobrega KHS
AD  - Diagnostic Centre for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, RS, Brazil.
FAU - de Andrade, Bruno Augusto Benevenuto
AU  - de Andrade BAB
AD  - Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Romanach, Mario Jose
AU  - Romanach MJ
AD  - Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Agostini, Michelle
AU  - Agostini M
AD  - Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Nonaka, Cassiano Francisco Weege
AU  - Nonaka CFW
AD  - Department of Dentistry, Universidade Estadual da Paraiba, Campina Grande, PB, 
      Brazil.
FAU - Alves, Pollianna Muniz
AU  - Alves PM
AD  - Department of Dentistry, Universidade Estadual da Paraiba, Campina Grande, PB, 
      Brazil.
FAU - Pontes, Helder Antonio Rebelo
AU  - Pontes HAR
AD  - Service of Oral Pathology, Hospital Universitario Joao de Barros Barreto, 
      Universidade Federal do Para, Belem, PA, Brazil.
FAU - Rivero, Luis Fernando
AU  - Rivero LF
AD  - Department of Pathology, Faculty of Medicine, Universidade Federal do Rio Grande 
      do Sul, Porto Alegre, RS, Brazil.
FAU - de Souza, Lelia Batista
AU  - de Souza LB
AD  - Postgraduate Program in Oral Pathology, School of Dentistry, Universidade Federal 
      do Rio Grande do Norte, Natal, RN, Brazil.
FAU - Trierveiler, Marilia
AU  - Trierveiler M
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade 
      de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Mendonca, Elismauro Francisco
AU  - Mendonca EF
AD  - Department of Stomatology (Oral Pathology), School of Dentistry, Universidade 
      Federal de Goias, Goiania, GO, Brazil.
FAU - Gomes, Ana Paula Neutzling
AU  - Gomes APN
AD  - Diagnostic Centre for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, RS, Brazil.
FAU - Martins, Manoela Domingues
AU  - Martins MD
AD  - Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio 
      Grande do Sul, Porto Alegre, RS, Brazil.
AD  - Department of Oral Medicine, Hospital de Clinicas de Porto Alegre, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Andrade, Emanuel Savio de Souza
AU  - Andrade ESS
AD  - Department of Oral and Maxillofacial Surgery and Pathology, School of Dentistry, 
      Universidade de Pernambuco, Camaragibe, PE, Brazil.
FAU - da Silveira, Marcia Maria Fonseca
AU  - da Silveira MMF
AD  - Department of Oral and Maxillofacial Surgery and Pathology, School of Dentistry, 
      Universidade de Pernambuco, Camaragibe, PE, Brazil.
FAU - Sobral, Ana Paula Veras
AU  - Sobral APV
AD  - Department of Oral and Maxillofacial Surgery and Pathology, School of Dentistry, 
      Universidade de Pernambuco, Camaragibe, PE, Brazil.
FAU - Mesquita, Ricardo Alves
AU  - Mesquita RA
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
LA  - eng
GR  - #305493/2018-3/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
GR  - #455644/2018-1/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200219
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - Actinic cheilitis
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil/epidemiology
MH  - Cheilitis/epidemiology/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lip Neoplasms/epidemiology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/epidemiology/*pathology
MH  - Young Adult
PMC - PMC7669919
OTO - NOTNLM
OT  - Actinic cheilitis
OT  - Epidemiology
OT  - Lip neoplasms
OT  - Oral cancer
OT  - Squamous cell carcinoma
OT  - UV radiation
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/02/23 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/02/19
CRDT- 2020/02/21 06:00
PHST- 2019/11/06 00:00 [received]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/02/02 00:00 [revised]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2021/02/19 00:00 [pmc-release]
AID - 10.1007/s12105-020-01142-2 [pii]
AID - 1142 [pii]
AID - 10.1007/s12105-020-01142-2 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2020 Dec;14(4):899-908. doi: 10.1007/s12105-020-01142-2. Epub 
      2020 Feb 19.